Levoleucovorin calcium and Hyperammonaemia - a phase IV clinical study of FDA data

Summary:

Hyperammonaemia is reported as a side effect among people who take Levoleucovorin calcium (levoleucovorin calcium), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Fluorouracil, and have Colon cancer.

The phase IV clinical study analyzes which people have Hyperammonaemia when taking Levoleucovorin calcium. It is created by eHealthMe based on reports of 2,464 people who have side effects when taking Levoleucovorin calcium from the FDA, and is updated regularly.

What is Levoleucovorin calcium?

Levoleucovorin calcium has active ingredients of levoleucovorin calcium. eHealthMe is studying from 2,464 Levoleucovorin calcium users. Check the latest studies of Levoleucovorin calcium.

What is Hyperammonaemia?

Hyperammonaemia is found to be associated with 397 drugs and 562 conditions by eHealthMe. Check the latest studies of Hyperammonaemia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

2,464 people reported to have side effects when taking Levoleucovorin calcium.
Among them, 39 people (1.58%) have Hyperammonaemia.

Could Levoleucovorin calcium cause Hyperammonaemia?

Among these 39 people:

How long have people been on Levoleucovorin calcium when they have Hyperammonaemia? *

What is the gender of people who have Hyperammonaemia when taking Levoleucovorin calcium? *

female: 37.84 %
male: 62.16 %

What is the age of people who have Hyperammonaemia when taking Levoleucovorin calcium? *

What are other drugs people take besides Levoleucovorin calcium? *

Fluorouracil: 36 people, 92.31%
Oxaliplatin: 30 people, 76.92%
Avastin: 11 people, 28.21%
Irinotecan Hydrochloride: 4 people, 10.26%
Dexamethasone Sodium Phosphate: 3 people, 7.69%
Xeloda: 3 people, 7.69%
Kytril: 2 people, 5.13%
Vectibix: 2 people, 5.13%
Onivyde: 2 people, 5.13%
Magnesium Oxide: 2 people, 5.13%

What are other side effects people have besides Hyperammonaemia? *

Altered State Of Consciousness (altered state of mind): 9 people, 23.08%
Hepatic Encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure): 4 people, 10.26%
Hepatic Failure (liver failure): 4 people, 10.26%
Nausea And Vomiting: 4 people, 10.26%
Lactic Acidosis (low ph in body tissues): 3 people, 7.69%
Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 2 people, 5.13%
Hepatic Function Abnormal: 2 people, 5.13%
Hepatocellular Injury (liver injury): 2 people, 5.13%
Hyperammonaemic Encephalopathy (excess of ammonia in the blood, disorder or disease of the brain): 2 people, 5.13%
Dermatitis Acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis): 2 people, 5.13%

What are the existing conditions these people have? *

Colon Cancer: 17 people, 43.59%
Rectal Cancer (cancer of rectum): 6 people, 15.38%
Large Intestine Carcinoma (cancer of large intestine): 4 people, 10.26%
Pancreatic Carcinoma (pancreatic cancer): 3 people, 7.69%
Colon Cancer Metastatic (cancer of colon spreads to other part of body): 3 people, 7.69%
Colon Cancer Recurrent: 3 people, 7.69%
Urination - Painful: 1 person, 2.56%
Colon Cancer Stage Iii: 1 person, 2.56%
Bleeding Disorders: 1 person, 2.56%
Brain Oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 1 person, 2.56%

* Approximation only. Some reports may have incomplete information.

Do you take Levoleucovorin calcium and have Hyperammonaemia?

- Check whether Hyperammonaemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Levoleucovorin calcium:

Levoleucovorin calcium (2,464 reports)

Hyperammonaemia treatments and more:

Hyperammonaemia (6,053 reports)

Browse all side effects of Levoleucovorin calcium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperammonaemia:

Hyperammonaemia (397 drugs)

Browse all the conditions that are associated with Hyperammonaemia:

Hyperammonaemia (562 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on levoleucovorin calcium (the active ingredients of Levoleucovorin calcium) and Levoleucovorin calcium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.