Levonorgestrel and Endometriosis - a phase IV clinical study of FDA data

Summary:

Endometriosis is reported as a side effect among people who take Levonorgestrel (levonorgestrel), especially for people who are 30-39 old, also take Progesterone, and have Dysmenorrhea.

The phase IV clinical study analyzes which people have Endometriosis when taking Levonorgestrel. It is created by eHealthMe based on reports of 3,996 people who have side effects when taking Levonorgestrel from the FDA, and is updated regularly.

What is Levonorgestrel?

Levonorgestrel has active ingredients of levonorgestrel. It is often used in birth control. eHealthMe is studying from 4,186 Levonorgestrel users. Check the latest studies of Levonorgestrel.

What is Endometriosis?

Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain) is found to be associated with 421 drugs and 562 conditions by eHealthMe. Check the latest studies of Endometriosis.

On Jul, 31, 2026

3,996 people reported to have side effects when taking Levonorgestrel.
Among them, 17 people (0.43%) have Endometriosis.

Could Levonorgestrel cause Endometriosis?

Among these 17 people:

What is the age of people who have Endometriosis when taking Levonorgestrel? *

What are other drugs people take besides Levonorgestrel? *

What are other side effects people have besides Endometriosis? *

Pelvic Inflammatory Disease: 3 people, 17.65%
Pelvic Inflammatory Disease (Pid): 3 people, 17.65%
Pleural Effusion (water on the lungs): 2 people, 11.76%
Drug Ineffective: 2 people, 11.76%
Oedema Peripheral (superficial swelling): 2 people, 11.76%
Haematosalpinx (bleeding into the fallopian tubes): 2 people, 11.76%
Pelvic Abscess: 2 people, 11.76%
Genital Haemorrhage (bleeding from genital): 2 people, 11.76%
Pelvic Pain: 2 people, 11.76%
Polycystic Ovary Disease (cysts in the ovaries that occurs when the follicle stops developing): 2 people, 11.76%

What are the existing conditions these people have? *

Dysmenorrhea (painful menstruation): 3 people, 17.65%
Uterine Haemorrhage (uterine bleeding): 1 person, 5.88%
Premature Menopause: 1 person, 5.88%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 5.88%
Drowsiness: 1 person, 5.88%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 5.88%
Adenomyosis (presence of ectopic glandular tissue found in muscle): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Levonorgestrel and have Endometriosis?

- Check whether Endometriosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Levonorgestrel:

Levonorgestrel (4,186 reports)

Endometriosis treatments and more:

Endometriosis (19,678 reports)

Browse all side effects of Levonorgestrel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Endometriosis:

Endometriosis (421 drugs)

Browse all the conditions that are associated with Endometriosis:

Endometriosis (562 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on levonorgestrel (the active ingredients of Levonorgestrel) and Levonorgestrel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.