Levothroid and Blood creatine phosphokinase increased - a phase IV clinical study of FDA data

Summary:

Blood creatine phosphokinase increased is reported as a side effect among people who take Levothroid (levothyroxine sodium), especially for people who are female, 60+ old, also take Imdur, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Blood creatine phosphokinase increased when taking Levothroid. It is created by eHealthMe based on reports of 8,088 people who have side effects when taking Levothroid from the FDA, and is updated regularly.

What is Levothroid?

Levothroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 8,974 Levothroid users. Check the latest studies of Levothroid.

What is Blood creatine phosphokinase increased?

Blood creatine phosphokinase increased is found to be associated with 1,498 drugs and 2,095 conditions by eHealthMe. Check the latest studies of Blood creatine phosphokinase increased.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

8,088 people reported to have side effects when taking Levothroid.
Among them, 48 people (0.59%) have Blood creatine phosphokinase increased.

Could Levothroid cause Blood creatine phosphokinase increased?

Among these 48 people:

What is the gender of people who have Blood creatine phosphokinase increased when taking Levothroid? *

female: 56.25 %
male: 43.75 %

What is the age of people who have Blood creatine phosphokinase increased when taking Levothroid? *

What are other drugs people take besides Levothroid? *

What are other side effects people have besides Blood creatine phosphokinase increased? *

Fatigue (feeling of tiredness): 13 people, 27.08%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 22.92%
Dyspnea (difficult or laboured breathing): 11 people, 22.92%
Fever: 11 people, 22.92%
High Blood Cholesterol: 10 people, 20.83%
Stable Angina (a constant chest pain): 10 people, 20.83%
Gouty Arthritis (joint inflammation with crystal formation): 9 people, 18.75%
Malignant Hypertension (a hypertensive emergency is a condition in which elevated blood pressure results in target organ damage): 9 people, 18.75%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 9 people, 18.75%
Nasal Discomfort: 9 people, 18.75%

What are the existing conditions these people have? *

High Blood Cholesterol: 4 people, 8.33%
Cardiac Disorder: 3 people, 6.25%
Indigestion: 3 people, 6.25%
Stress Symptoms: 2 people, 4.17%
Pain: 2 people, 4.17%
Osteopenia (a condition where bone mineral density is lower than normal): 2 people, 4.17%
High Blood Pressure: 1 person, 2.08%
Bipolar Disorder (mood disorder): 1 person, 2.08%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 2.08%
Depression: 1 person, 2.08%

* Approximation only. Some reports may have incomplete information.

Do you take Levothroid and have Blood creatine phosphokinase increased?

- Check whether Blood creatine phosphokinase increased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Levothroid:

Levothroid (8,974 reports)

Blood creatine phosphokinase increased treatments and more:

Blood creatine phosphokinase increased (46,724 reports)

How severe was Blood creatine phosphokinase increased and when was it recovered:

Blood creatine phosphokinase increased in Levothroid

Expand to all the drugs that have ingredients of levothyroxine sodium:

Blood creatine phosphokinase increased and drugs with ingredients of levothyroxine sodium (1,463 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Levothroid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Blood creatine phosphokinase increased:

Blood creatine phosphokinase increased (1,498 drugs)

Browse all the conditions that are associated with Blood creatine phosphokinase increased:

Blood creatine phosphokinase increased (2,095 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on levothyroxine sodium (the active ingredients of Levothroid) and Levothroid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.