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Libtayo and Headache - a phase IV clinical study of FDA data

Summary:

Headache is reported as a side effect among people who take Libtayo (cemiplimab-rwlc), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Acitretin, and have Squamous cell carcinoma of skin.

The phase IV clinical study analyzes which people have Headache when taking Libtayo. It is created by eHealthMe based on reports of 1,159 people who have side effects when taking Libtayo from the FDA, and is updated regularly.

What is Libtayo?

Libtayo has active ingredients of cemiplimab-rwlc. eHealthMe is studying from 1,161 Libtayo users. Check the latest studies of Libtayo.

What is Headache?

Headache (pain in head) is found to be associated with 3,753 drugs and 5,772 conditions by eHealthMe. Check the latest studies of Headache.

On Jul, 10, 2026

1,159 people reported to have side effects when taking Libtayo.
Among them, 13 people (1.12%) have Headache.

Could Libtayo cause Headache?

Among these 13 people:

How long have people been on Libtayo when they have Headache? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 100 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Headache when taking Libtayo? *

  • female: 100 %
  • male: 0.0 %

What is the age of people who have Headache when taking Libtayo? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 100 %

What are other drugs people take besides Libtayo? *

  1. Sulfasalazine: 1 person, 7.69%
  2. Prozac: 1 person, 7.69%
  3. Prednisone: 1 person, 7.69%
  4. Prednisolone: 1 person, 7.69%
  5. Acitretin: 1 person, 7.69%

What are other side effects people have besides Headache? *

  1. Fatigue (feeling of tiredness): 6 people, 46.15%
  2. Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 4 people, 30.77%
  3. Fever: 4 people, 30.77%
  4. Chills (felling of cold): 4 people, 30.77%
  5. General Physical Health Deterioration (weak health status): 3 people, 23.08%
  6. Respiratory Tract Infection: 3 people, 23.08%
  7. Oropharyngeal Pain: 3 people, 23.08%
  8. Pain In Extremity: 3 people, 23.08%
  9. Constipation: 3 people, 23.08%
  10. Hyperhidrosis (abnormally increased sweating): 3 people, 23.08%

What are the existing conditions these people have? *

  1. Squamous Cell Carcinoma Of Skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin): 6 people, 46.15%
  2. Squamous Cell Carcinoma (a cancer of a kind of epithelial cell): 3 people, 23.08%
  3. Skin Cancer: 1 person, 7.69%
  4. Metastatic Squamous Cell Carcinoma (cancer of squamous cells spreads to other part): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Libtayo and have Headache?

- Check whether Headache is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Libtayo:

Headache treatments and more:

How severe was Headache and when was it recovered:

Expand to all the drugs that have ingredients of cemiplimab-rwlc:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Libtayo:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Headache:

Browse all the conditions that are associated with Headache:

How the study uses the data?

The study uses data from the FDA. It is based on cemiplimab-rwlc (the active ingredients of Libtayo) and Libtayo (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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