Lidocaine and Cardiotoxicity - a phase IV clinical study of FDA data

Summary:

Cardiotoxicity is reported as a side effect among people who take Lidocaine (lidocaine), especially for people who are female, 40-49 old, also take Diazepam, and have Epilepsy.

The phase IV clinical study analyzes which people have Cardiotoxicity when taking Lidocaine. It is created by eHealthMe based on reports of 27,239 people who have side effects when taking Lidocaine from the FDA, and is updated regularly.

What is Lidocaine?

Lidocaine has active ingredients of lidocaine. It is often used in pain. eHealthMe is studying from 27,555 Lidocaine users. Check the latest studies of Lidocaine.

What is Cardiotoxicity?

Cardiotoxicity (damage to the heart muscle) is found to be associated with 384 drugs and 511 conditions by eHealthMe. Check the latest studies of Cardiotoxicity.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

27,239 people reported to have side effects when taking Lidocaine.
Among them, 13 people (0.05%) have Cardiotoxicity.

Among these 13 people:

What is the gender of people who have Cardiotoxicity when taking Lidocaine? *

female: 54.55 %
male: 45.45 %

What is the age of people who have Cardiotoxicity when taking Lidocaine? *

What are other drugs people take besides Lidocaine? *

Sodium Bicarbonate: 2 people, 15.38%
Epinephrine: 2 people, 15.38%
Diazepam: 2 people, 15.38%
Zyprexa Relprevv: 1 person, 7.69%
Dobutamine Hydrochloride: 1 person, 7.69%
Lorazepam: 1 person, 7.69%
Levetiracetam: 1 person, 7.69%
Latuda: 1 person, 7.69%
Klonopin: 1 person, 7.69%
Haloperidol: 1 person, 7.69%

What are other side effects people have besides Cardiotoxicity? *

Overdose: 5 people, 38.46%
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system): 4 people, 30.77%
Drug Ineffective: 4 people, 30.77%
Ventricular Tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 4 people, 30.77%
Agitation (state of anxiety or nervous excitement): 4 people, 30.77%
Electrocardiogram Qrs Complex Prolonged: 3 people, 23.08%
Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch): 2 people, 15.38%
Muscle Twitching: 2 people, 15.38%
Confusion: 2 people, 15.38%
Drug Level Increased: 2 people, 15.38%

What are the existing conditions these people have? *

Ventricular Tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 2 people, 15.38%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 2 people, 15.38%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 7.69%
Sedation: 1 person, 7.69%
Neuromuscular Blockade: 1 person, 7.69%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 7.69%
Mood Swings (an extreme or rapid change in mood): 1 person, 7.69%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 1 person, 7.69%
Insomnia (sleeplessness): 1 person, 7.69%
Aplastic Anemia: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Lidocaine and have Cardiotoxicity?

- Check whether Cardiotoxicity is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lidocaine:

Lidocaine (27,555 reports)

Cardiotoxicity treatments and more:

Cardiotoxicity (8,120 reports)

Browse all side effects of Lidocaine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cardiotoxicity:

Cardiotoxicity (384 drugs)

Browse all the conditions that are associated with Cardiotoxicity:

Cardiotoxicity (511 conditions)

Related publications that referenced our studies

Alam, S., Illo, C., Ma, Y. T., & Punia, P. , "Gemcitabine-induced cardiotoxicity in patients receiving adjuvant chemotherapy for pancreatic cancer: a case series", Case reports in oncology, 2018 Jan .
Alam, S., Illo, C., Ma, Y. T., & Punia, P. , "Gemcitabine-induced cardiotoxicity in patients receiving adjuvant chemotherapy for pancreatic cancer: a case series", Case reports in oncology, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on lidocaine (the active ingredients of Lidocaine) and Lidocaine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.