Linzess and Injection site rash - a phase IV clinical study of FDA data

Summary:

Injection site rash is reported as a side effect among people who take Linzess (linaclotide), especially for people who are female, 60+ old, also take Potassium, and have Asthma.

The phase IV clinical study analyzes which people have Injection site rash when taking Linzess. It is created by eHealthMe based on reports of 23,558 people who have side effects when taking Linzess from the FDA, and is updated regularly.

What is Linzess?

Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 24,086 Linzess users. Check the latest studies of Linzess.

What is Injection site rash?

Injection site rash is found to be associated with 709 drugs and 713 conditions by eHealthMe. Check the latest studies of Injection site rash.

On Jul, 05, 2026

23,558 people reported to have side effects when taking Linzess.
Among them, 18 people (0.08%) have Injection site rash.

Could Linzess cause Injection site rash?

Among these 18 people:

What is the gender of people who have Injection site rash when taking Linzess? *

female: 88.89 %
male: 11.11 %

What is the age of people who have Injection site rash when taking Linzess? *

What are other drugs people take besides Linzess? *

What are other side effects people have besides Injection site rash? *

Injection Site Erythema (redness at injection site): 10 people, 55.56%
Injection Site Swelling: 7 people, 38.89%
Fatigue (feeling of tiredness): 5 people, 27.78%
Joint Pain: 4 people, 22.22%
Injection Site Pruritus (severe itching at injection site): 4 people, 22.22%
Injection Site Pain: 4 people, 22.22%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 4 people, 22.22%
Injection Site Warmth: 3 people, 16.67%
Asthma: 3 people, 16.67%
Muscle Aches (muscle pain): 3 people, 16.67%

What are the existing conditions these people have? *

Asthma: 4 people, 22.22%
Osteoporosis (bones weak and more likely to break): 3 people, 16.67%
Ankylosing Spondylitis (type of arthritis affecting the spine): 3 people, 16.67%
Spondyloarthropathy (any joint disease of the vertebral column): 2 people, 11.11%
Skin Irritation: 2 people, 11.11%
Immunodeficiency Common Variable: 2 people, 11.11%
Immune System Disorder: 2 people, 11.11%
Idiopathic Urticaria (allergic reactions, presence of hives with unknown cause): 2 people, 11.11%
Hereditary Angioedema (recurrent episodes of severe swelling): 2 people, 11.11%
Bone Loss: 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

Do you take Linzess and have Injection site rash?

- Check whether Injection site rash is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Linzess:

Linzess (24,086 reports)

Browse all side effects of Linzess:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Injection site rash:

Injection site rash (709 drugs)

Browse all the conditions that are associated with Injection site rash:

Injection site rash (713 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on linaclotide (the active ingredients of Linzess) and Linzess (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.