Linzess and Sinus congestion - a phase IV clinical study of FDA data

Summary:

Sinus congestion is reported as a side effect among people who take Linzess (linaclotide), especially for people who are female, 60+ old, also take Magnesium, and have Immunodeficiency common variable.

The phase IV clinical study analyzes which people have Sinus congestion when taking Linzess. It is created by eHealthMe based on reports of 23,558 people who have side effects when taking Linzess from the FDA, and is updated regularly.

What is Linzess?

Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 24,086 Linzess users. Check the latest studies of Linzess.

What is Sinus congestion?

Sinus congestion (blockage of sinus) is found to be associated with 1,006 drugs and 955 conditions by eHealthMe. Check the latest studies of Sinus congestion.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

23,558 people reported to have side effects when taking Linzess.
Among them, 18 people (0.08%) have Sinus congestion.

Among these 18 people:

What is the gender of people who have Sinus congestion when taking Linzess? *

female: 82.35 %
male: 17.65 %

What is the age of people who have Sinus congestion when taking Linzess? *

What are other drugs people take besides Linzess? *

What are other side effects people have besides Sinus congestion? *

Nausea (feeling of having an urge to vomit): 9 people, 50.00%
Nausea And Vomiting: 8 people, 44.44%
Diarrhea: 8 people, 44.44%
Urinary Tract Infection: 7 people, 38.89%
Sinusitis (inflammation of sinus): 6 people, 33.33%
Nasopharyngitis (inflammation of the nasopharynx): 6 people, 33.33%
Gastroenteritis Viral (inflammation of stomach and intestine caused by virus infection): 5 people, 27.78%
Headache (pain in head): 5 people, 27.78%
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 5 people, 27.78%
Malaise (a feeling of general discomfort or uneasiness): 4 people, 22.22%

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 6 people, 33.33%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 22.22%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 11.11%
Pain: 2 people, 11.11%
Muscle Spasms (muscle contraction): 2 people, 11.11%
Mouth Ulcers: 2 people, 11.11%
Intervertebral Disc Protrusion (spinal disc protrusion): 2 people, 11.11%
Impaired Gastric Emptying: 2 people, 11.11%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 5.56%
Pituitary-Dependent Cushing's Syndrome (pituitary dependent hypercortisolism): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Linzess and have Sinus congestion?

- Check whether Sinus congestion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Linzess:

Linzess (24,086 reports)

Sinus congestion treatments and more:

Sinus congestion (21,241 reports)

Browse all side effects of Linzess:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus congestion:

Sinus congestion (1,006 drugs)

Browse all the conditions that are associated with Sinus congestion:

Sinus congestion (955 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on linaclotide (the active ingredients of Linzess) and Linzess (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.