Linzess and Thirst - a phase IV clinical study of FDA data

Summary:

Thirst is reported as a side effect among people who take Linzess (linaclotide), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Vitamin D, and have Hypothyroidism.

The phase IV clinical study analyzes which people have Thirst when taking Linzess. It is created by eHealthMe based on reports of 23,558 people who have side effects when taking Linzess from the FDA, and is updated regularly.

What is Linzess?

Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 24,086 Linzess users. Check the latest studies of Linzess.

What is Thirst?

Thirst is found to be associated with 1,170 drugs and 1,323 conditions by eHealthMe. Check the latest studies of Thirst.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

23,558 people reported to have side effects when taking Linzess.
Among them, 32 people (0.14%) have Thirst.

Among these 32 people:

How long have people been on Linzess when they have Thirst? *

What is the gender of people who have Thirst when taking Linzess? *

female: 74.19 %
male: 25.81 %

What is the age of people who have Thirst when taking Linzess? *

What are other drugs people take besides Linzess? *

What are other side effects people have besides Thirst? *

Diarrhea: 8 people, 25.00%
Weight Decreased: 7 people, 21.88%
Dry Mouth: 6 people, 18.75%
Abdominal Distension: 5 people, 15.62%
Nausea (feeling of having an urge to vomit): 5 people, 15.62%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 5 people, 15.62%
Drug Ineffective: 5 people, 15.62%
Dizziness: 5 people, 15.62%
Fatigue (feeling of tiredness): 4 people, 12.50%
Muscle Spasms (muscle contraction): 4 people, 12.50%

What are the existing conditions these people have? *

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 12.50%
Abdominal Discomfort: 3 people, 9.38%
Hyperkalemia (damage to or disease of the kidney): 3 people, 9.38%
High Blood Pressure: 2 people, 6.25%
High Blood Cholesterol: 2 people, 6.25%
Seasonal Allergy (allergic condition due to certain season): 2 people, 6.25%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 3.12%
Gait Disturbance: 1 person, 3.12%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 3.12%
Asthma: 1 person, 3.12%

* Approximation only. Some reports may have incomplete information.

Do you take Linzess and have Thirst?

- Check whether Thirst is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Linzess:

Linzess (24,086 reports)

Thirst treatments and more:

Thirst (21,000 reports)

Browse all side effects of Linzess:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Thirst:

Thirst (1,170 drugs)

Browse all the conditions that are associated with Thirst:

Thirst (1,323 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on linaclotide (the active ingredients of Linzess) and Linzess (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.