Lipitor and Application site discomfort - a phase IV clinical study of FDA data

Summary:

Application site discomfort is reported as a side effect among people who take Lipitor (atorvastatin calcium), especially for people who are female, 60+ old, also take Picato, and have Actinic keratosis.

The phase IV clinical study analyzes which people have Application site discomfort when taking Lipitor. It is created by eHealthMe based on reports of 251,142 people who have side effects when taking Lipitor from the FDA, and is updated regularly.

What is Lipitor?

Lipitor has active ingredients of atorvastatin calcium. It is often used in high blood cholesterol. eHealthMe is studying from 259,047 Lipitor users. Check the latest studies of Lipitor.

What is Application site discomfort?

Application site discomfort is found to be associated with 91 drugs and 255 conditions by eHealthMe. Check the latest studies of Application site discomfort.

On Jul, 15, 2026

251,142 people reported to have side effects when taking Lipitor.
Among them, 13 people (0.01%) have Application site discomfort.

Could Lipitor cause Application site discomfort?

Among these 13 people:

What is the gender of people who have Application site discomfort when taking Lipitor? *

female: 66.67 %
male: 33.33 %

What is the age of people who have Application site discomfort when taking Lipitor? *

What are other drugs people take besides Lipitor? *

What are other side effects people have besides Application site discomfort? *

Application Site Erythema (redness of the skin at application site): 10 people, 76.92%
Application Site Pain: 7 people, 53.85%
Application Site Burn: 5 people, 38.46%
Application Site Discoloration: 5 people, 38.46%
Application Site Exfoliation (application site removal of the oldest dead skin cells on the skin's outermost surface): 4 people, 30.77%
Application Site Irritation: 4 people, 30.77%
Application Site Pruritus (application site severe itching of the skin): 4 people, 30.77%
Application Site Warmth: 3 people, 23.08%
Application Site Erosion: 3 people, 23.08%
Application Site Scar: 3 people, 23.08%

What are the existing conditions these people have? *

Precancerous Cells Present: 2 people, 15.38%
Migraine (headache): 2 people, 15.38%
Indigestion: 2 people, 15.38%
Headache (pain in head): 2 people, 15.38%
Actinic Keratosis (skin disease due to sun exposure): 2 people, 15.38%
Precancerous Skin Lesion: 1 person, 7.69%
Mycosis Fungoides (lymphocytes (a type of white blood cell) become malignant (cancerous) and affect the skin): 1 person, 7.69%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 7.69%
Blood Testosterone Decreased: 1 person, 7.69%
Back Pain: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Lipitor and have Application site discomfort?

- Check whether Application site discomfort is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lipitor:

Lipitor (259,047 reports)

Browse all side effects of Lipitor:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Application site discomfort:

Application site discomfort (91 drugs)

Browse all the conditions that are associated with Application site discomfort:

Application site discomfort (255 conditions)

Related publications that referenced our studies

Proti? D, Balti? S, Stupar N, Pavlov-Dolijanovi? S, Mugo?a S, Todorovi? Z, "A case of myositis with immunological background associated with statin use", Open Medicine, 2014 Oct .
Goldie MP, "Atorvastatin: a new treatment for periodontal disease?", , 2012 Jan .
Proti? D, Balti? S, Stupar N, Pavlov-Dolijanovi? S, Mugo?a S, Todorovi? Z, "A case of myositis with immunological background associated with statin use", Open Medicine, 2014 Oct .
Goldie MP, "Atorvastatin: a new treatment for periodontal disease?", , 2012 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on atorvastatin calcium (the active ingredients of Lipitor) and Lipitor (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.