Lodine and Hyponatraemia aggravated - a phase IV clinical study of FDA data

Summary:

Hyponatraemia aggravated is reported as a side effect among people who take Lodine (etodolac), especially for people who are male, 50-59 old, also take Thalidomide, and have Depression.

The phase IV clinical study analyzes which people have Hyponatraemia aggravated when taking Lodine. It is created by eHealthMe based on reports of 3,671 people who have side effects when taking Lodine from the FDA, and is updated regularly.

What is Lodine?

Lodine has active ingredients of etodolac. It is often used in pain. eHealthMe is studying from 3,846 Lodine users. Check the latest studies of Lodine.

What is Hyponatraemia aggravated?

Hyponatraemia aggravated (abnormally low concentrations of sodium ions in the circulating blood) is found to be associated with 1,499 drugs and 543 conditions by eHealthMe. Check the latest studies of Hyponatraemia aggravated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

3,671 people reported to have side effects when taking Lodine.
Among them, 15 people (0.41%) have Hyponatraemia aggravated.

Could Lodine cause Hyponatraemia aggravated?

Among these 15 people:

What is the gender of people who have Hyponatraemia aggravated when taking Lodine? *

female: 33.33 %
male: 66.67 %

What is the age of people who have Hyponatraemia aggravated when taking Lodine? *

What are other drugs people take besides Lodine? *

What are other side effects people have besides Hyponatraemia aggravated? *

Alpha Haemolytic Streptococcal Infection (infections with alpha-haemolytic strep bacteria are common; many strains live naturally in humans): 9 people, 60.00%
Pleural Effusion (water on the lungs): 9 people, 60.00%
Cardiac Failure Congestive: 9 people, 60.00%
Dyspnea (difficult or laboured breathing): 8 people, 53.33%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 8 people, 53.33%
Constipation: 8 people, 53.33%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 8 people, 53.33%
Neuropathy Peripheral (surface nerve damage): 8 people, 53.33%
Nephrosclerosis (hardening of the kidney due to renovascular disease): 8 people, 53.33%
Depression: 8 people, 53.33%

What are the existing conditions these people have? *

Depression: 9 people, 60.00%
Acute Kidney Failure: 8 people, 53.33%
Multiple Myeloma (cancer of the plasma cells): 2 people, 13.33%
Migraine (headache): 1 person, 6.67%
High Blood Pressure: 1 person, 6.67%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Lodine and have Hyponatraemia aggravated?

- Check whether Hyponatraemia aggravated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lodine:

Lodine (3,846 reports)

Browse all side effects of Lodine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyponatraemia aggravated:

Hyponatraemia aggravated (1,500 drugs)

Browse all the conditions that are associated with Hyponatraemia aggravated:

Hyponatraemia aggravated (543 conditions)

Related publications that referenced our studies

Liao KF, Cheng KC, Lin CL, Lai SW, "Etodolac and the risk of acute pancreatitis", BioMedicine, 2017 Jan .
Liao KF, Cheng KC, Lin CL, Lai SW, "Etodolac and the risk of acute pancreatitis", BioMedicine, 2017 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on etodolac (the active ingredients of Lodine) and Lodine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.