Loestrin 24 fe and Headache - a phase IV clinical study of FDA data

Summary:

Headache is reported as a side effect among people who take Loestrin 24 fe (ethinyl estradiol; norethindrone acetate), especially for people who are female, 30-39 old, have been taking the drug for < 1 month also take Toprol-Xl, and have Heavy or prolong menstrual bleeding.

The phase IV clinical study analyzes which people have Headache when taking Loestrin 24 fe. It is created by eHealthMe based on reports of 422 people who have side effects when taking Loestrin 24 fe from the FDA, and is updated regularly.

What is Loestrin 24 fe?

Loestrin 24 fe has active ingredients of ethinyl estradiol; norethindrone acetate. It is often used in birth control. eHealthMe is studying from 1,234 Loestrin 24 fe users. Check the latest studies of Loestrin 24 fe.

What is Headache?

Headache (pain in head) is found to be associated with 3,749 drugs and 5,771 conditions by eHealthMe. Check the latest studies of Headache.

On Jul, 13, 2026

422 people reported to have side effects when taking Loestrin 24 fe.
Among them, 26 people (6.16%) have Headache.

Among these 26 people:

How long have people been on Loestrin 24 fe when they have Headache? *

What is the gender of people who have Headache when taking Loestrin 24 fe? *

female: 100 %
male: 0.0 %

What is the age of people who have Headache when taking Loestrin 24 fe? *

What are other drugs people take besides Loestrin 24 fe? *

What are other side effects people have besides Headache? *

Nausea (feeling of having an urge to vomit): 10 people, 38.46%
Nausea And Vomiting: 6 people, 23.08%
Weakness: 5 people, 19.23%
Depression: 4 people, 15.38%
Weight Increased: 3 people, 11.54%
Muscle Spasms (muscle contraction): 3 people, 11.54%
Pain: 3 people, 11.54%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 3 people, 11.54%
Muscle Tightness: 3 people, 11.54%
Stress And Anxiety: 3 people, 11.54%

What are the existing conditions these people have? *

Heavy Or Prolong Menstrual Bleeding: 3 people, 11.54%
Vaginal Bleeding Between Periods: 1 person, 3.85%
Stress And Anxiety: 1 person, 3.85%
Premenstrual Syndrome: 1 person, 3.85%
Panic Disorder: 1 person, 3.85%
Ovarian Cyst Ruptured (tear in fluid filled sac of the ovary): 1 person, 3.85%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 3.85%
Multiple Myeloma (cancer of the plasma cells): 1 person, 3.85%
Dysmenorrhea (painful menstruation): 1 person, 3.85%
Dysfunctional Uterine Bleeding (Dub): 1 person, 3.85%

* Approximation only. Some reports may have incomplete information.

Do you take Loestrin 24 fe and have Headache?

- Check whether Headache is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Loestrin 24 fe:

Loestrin 24 fe (1,234 reports)

Headache treatments and more:

Headache (756,642 reports)

How severe was Headache and when was it recovered:

Headache in Loestrin 24 fe

Expand to all the drugs that have ingredients of ethinyl estradiol; norethindrone acetate:

Headache and drugs with ingredients of ethinyl estradiol; norethindrone acetate (1,278 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Loestrin 24 fe:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Headache:

Headache (3,749 drugs)

Browse all the conditions that are associated with Headache:

Headache (5,771 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ethinyl estradiol; norethindrone acetate (the active ingredients of Loestrin 24 fe) and Loestrin 24 fe (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.