Lomotil and Sciatica - a phase IV clinical study of FDA data

Summary:

Sciatica is reported as a side effect among people who take Lomotil (atropine sulfate; diphenoxylate hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Synthroid, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Sciatica when taking Lomotil. It is created by eHealthMe based on reports of 18,891 people who have side effects when taking Lomotil from the FDA, and is updated regularly.

What is Lomotil?

Lomotil has active ingredients of atropine sulfate; diphenoxylate hydrochloride. It is often used in diarrhea. eHealthMe is studying from 19,184 Lomotil users. Check the latest studies of Lomotil.

What is Sciatica?

Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve) is found to be associated with 1,145 drugs and 1,431 conditions by eHealthMe. Check the latest studies of Sciatica.

On May, 01, 2026

18,891 people reported to have side effects when taking Lomotil.
Among them, 39 people (0.21%) have Sciatica.

Among these 39 people:

How long have people been on Lomotil when they have Sciatica? *

What is the gender of people who have Sciatica when taking Lomotil? *

female: 69.7 %
male: 30.3 %

What is the age of people who have Sciatica when taking Lomotil? *

What are other drugs people take besides Lomotil? *

What are other side effects people have besides Sciatica? *

Pain In Extremity: 20 people, 51.28%
Fall: 15 people, 38.46%
Osteoporosis (bones weak and more likely to break): 15 people, 38.46%
Ligament Sprain (ligament stretched): 14 people, 35.90%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 14 people, 35.90%
High Blood Pressure: 13 people, 33.33%
Swallowing Difficulty: 12 people, 30.77%
Infection: 12 people, 30.77%
Pneumonia: 10 people, 25.64%
Pain: 10 people, 25.64%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 20.51%
Osteopenia (a condition where bone mineral density is lower than normal): 6 people, 15.38%
Pain: 3 people, 7.69%
Multiple Myeloma (cancer of the plasma cells): 2 people, 5.13%
Stress And Anxiety: 2 people, 5.13%
Sleep Disorder: 2 people, 5.13%
Joint Pain: 1 person, 2.56%
Indigestion: 1 person, 2.56%
Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 2.56%
High Blood Pressure: 1 person, 2.56%

* Approximation only. Some reports may have incomplete information.

Do you take Lomotil and have Sciatica?

- Check whether Sciatica is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lomotil:

Lomotil (19,184 reports)

Sciatica treatments and more:

Sciatica (28,509 reports)

How severe was Sciatica and when was it recovered:

Sciatica in Lomotil

Expand to all the drugs that have ingredients of atropine sulfate; diphenoxylate hydrochloride:

Sciatica and drugs with ingredients of atropine sulfate; diphenoxylate hydrochloride

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lomotil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sciatica:

Sciatica (1,145 drugs)

Browse all the conditions that are associated with Sciatica:

Sciatica (1,431 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on atropine sulfate; diphenoxylate hydrochloride (the active ingredients of Lomotil) and Lomotil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.