Lonox and Pain - a phase IV clinical study of FDA data

Summary:

Pain is reported as a side effect among people who take Lonox (atropine sulfate; diphenoxylate hydrochloride), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Ambien, and have Hiv infection.

The phase IV clinical study analyzes which people have Pain when taking Lonox. It is created by eHealthMe based on reports of 374 people who have side effects when taking Lonox from the FDA, and is updated regularly.

What is Lonox?

Lonox has active ingredients of atropine sulfate; diphenoxylate hydrochloride. eHealthMe is studying from 376 Lonox users. Check the latest studies of Lonox.

What is Pain?

Pain is found to be associated with 3,815 drugs and 5,867 conditions by eHealthMe. Check the latest studies of Pain.

On Jul, 20, 2026

374 people reported to have side effects when taking Lonox.
Among them, 49 people (13.1%) have Pain.

Among these 49 people:

How long have people been on Lonox when they have Pain? *

What is the gender of people who have Pain when taking Lonox? *

female: 35.42 %
male: 64.58 %

What is the age of people who have Pain when taking Lonox? *

What are other drugs people take besides Lonox? *

What are other side effects people have besides Pain? *

Stress And Anxiety: 28 people, 57.14%
Emotional Distress: 21 people, 42.86%
Injury: 19 people, 38.78%
Dyspnea (difficult or laboured breathing): 17 people, 34.69%
Osteoporosis (bones weak and more likely to break): 16 people, 32.65%
Diarrhea: 16 people, 32.65%
Depression: 16 people, 32.65%
Osteopenia (a condition where bone mineral density is lower than normal): 16 people, 32.65%
High Blood Pressure: 15 people, 30.61%
Acute Kidney Failure: 14 people, 28.57%

What are the existing conditions these people have? *

Hiv Infection: 11 people, 22.45%
Stress And Anxiety: 9 people, 18.37%
High Blood Pressure: 4 people, 8.16%
Birth Control: 3 people, 6.12%
High Blood Cholesterol: 3 people, 6.12%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 6.12%
Metastases To Bone (cancer spreads to bone): 3 people, 6.12%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 6.12%
Colitis (inflammation of colon): 2 people, 4.08%
Insomnia (sleeplessness): 2 people, 4.08%

* Approximation only. Some reports may have incomplete information.

Do you take Lonox and have Pain?

- Check whether Pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lonox:

Lonox (376 reports)

Pain treatments and more:

Pain (1,140,594 reports)

How severe was Pain and when was it recovered:

Pain in Lonox

Expand to all the drugs that have ingredients of atropine sulfate; diphenoxylate hydrochloride:

Pain and drugs with ingredients of atropine sulfate; diphenoxylate hydrochloride (2,036 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lonox:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pain:

Pain (3,815 drugs)

Browse all the conditions that are associated with Pain:

Pain (5,867 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on atropine sulfate; diphenoxylate hydrochloride (the active ingredients of Lonox) and Lonox (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.