Lonsurf and Hot flush - a phase IV clinical study of FDA data

Summary:

Hot flush is reported as a side effect among people who take Lonsurf (tipiracil hydrochloride; trifluridine), especially for people who are 60+ old, have been taking the drug for < 1 month also take Lexapro, and have Colon cancer.

The phase IV clinical study analyzes which people have Hot flush when taking Lonsurf. It is created by eHealthMe based on reports of 10,075 people who have side effects when taking Lonsurf from the FDA, and is updated regularly.

What is Lonsurf?

Lonsurf has active ingredients of tipiracil hydrochloride; trifluridine. eHealthMe is studying from 10,077 Lonsurf users. Check the latest studies of Lonsurf.

What is Hot flush?

Hot flush (sudden feelings of heat) is found to be associated with 1,770 drugs and 2,343 conditions by eHealthMe. Check the latest studies of Hot flush.

On Jul, 13, 2026

10,075 people reported to have side effects when taking Lonsurf.
Among them, 13 people (0.13%) have Hot flush.

Among these 13 people:

How long have people been on Lonsurf when they have Hot flush? *

What is the age of people who have Hot flush when taking Lonsurf? *

What are other drugs people take besides Lonsurf? *

What are other side effects people have besides Hot flush? *

Nausea And Vomiting: 9 people, 69.23%
Nausea (feeling of having an urge to vomit): 8 people, 61.54%
Fatigue (feeling of tiredness): 6 people, 46.15%
Hypoaesthesia (reduced sense of touch or sensation): 5 people, 38.46%
Peripheral Swelling: 4 people, 30.77%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 4 people, 30.77%
Headache (pain in head): 3 people, 23.08%
Feeling Cold: 3 people, 23.08%
Fever: 3 people, 23.08%
Dehydration (dryness resulting from the removal of water): 3 people, 23.08%

What are the existing conditions these people have? *

Colon Cancer: 6 people, 46.15%
Rectal Cancer (cancer of rectum): 3 people, 23.08%
Rectosigmoid Cancer (cancer that originates in the rectum and sigmoid colon): 2 people, 15.38%
Colorectal Cancer Stage Iv (cancer of colon and rectal spreads to liver or lung): 2 people, 15.38%
Colon Cancer Metastatic (cancer of colon spreads to other part of body): 2 people, 15.38%
Carcinoid Tumor: 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

Do you take Lonsurf and have Hot flush?

- Check whether Hot flush is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lonsurf:

Lonsurf (10,077 reports)

Hot flush treatments and more:

Hot flush (91,208 reports)

How severe was Hot flush and when was it recovered:

Hot flush in Lonsurf

Expand to all the drugs that have ingredients of tipiracil hydrochloride; trifluridine:

Hot flush and drugs with ingredients of tipiracil hydrochloride; trifluridine

Sub-studies by age:

0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lonsurf:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hot flush:

Hot flush (1,770 drugs)

Browse all the conditions that are associated with Hot flush:

Hot flush (2,343 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tipiracil hydrochloride; trifluridine (the active ingredients of Lonsurf) and Lonsurf (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.