Loperamide hydrochloride and Polyneuropathy - a phase IV clinical study of FDA data

Summary:

Polyneuropathy is reported as a side effect among people who take Loperamide hydrochloride (loperamide hydrochloride), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Dexamethasone, and have Colorectal cancer metastatic.

The phase IV clinical study analyzes which people have Polyneuropathy when taking Loperamide hydrochloride. It is created by eHealthMe based on reports of 10,478 people who have side effects when taking Loperamide hydrochloride from the FDA, and is updated regularly.

What is Loperamide hydrochloride?

Loperamide hydrochloride has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 10,814 Loperamide hydrochloride users. Check the latest studies of Loperamide hydrochloride.

What is Polyneuropathy?

Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously) is found to be associated with 905 drugs and 944 conditions by eHealthMe. Check the latest studies of Polyneuropathy.

On Aug, 11, 2026

10,478 people reported to have side effects when taking Loperamide hydrochloride.
Among them, 11 people (0.1%) have Polyneuropathy.

Could Loperamide hydrochloride cause Polyneuropathy?

Among these 11 people:

How long have people been on Loperamide hydrochloride when they have Polyneuropathy? *

What is the gender of people who have Polyneuropathy when taking Loperamide hydrochloride? *

female: 20 %
male: 80 %

What is the age of people who have Polyneuropathy when taking Loperamide hydrochloride? *

What are other drugs people take besides Loperamide hydrochloride? *

Dexamethasone: 10 people, 90.91%
Fluorouracil: 7 people, 63.64%
Symbicort: 7 people, 63.64%
Oxaliplatin: 7 people, 63.64%
Aspirin: 7 people, 63.64%
Amlodipine Besylate: 6 people, 54.55%
Pantoprazole Sodium: 5 people, 45.45%
Granisetron Hydrochloride: 4 people, 36.36%
Nebivolol Hydrochloride: 2 people, 18.18%
Escitalopram: 2 people, 18.18%

What are other side effects people have besides Polyneuropathy? *

Rashes (redness): 3 people, 27.27%
Headache (pain in head): 2 people, 18.18%
Nasopharyngitis (inflammation of the nasopharynx): 1 person, 9.09%
Nail Abnormalities (abnormal nail): 1 person, 9.09%
Conjunctivitis (pink eye): 1 person, 9.09%

What are the existing conditions these people have? *

Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 8 people, 72.73%
Nausea (feeling of having an urge to vomit): 7 people, 63.64%
High Blood Pressure: 7 people, 63.64%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 7 people, 63.64%
Rashes (redness): 4 people, 36.36%
Gastric Ulcer (stomach ulcer): 4 people, 36.36%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

Do you take Loperamide hydrochloride and have Polyneuropathy?

- Check whether Polyneuropathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Loperamide hydrochloride:

Loperamide hydrochloride (10,814 reports)

Polyneuropathy treatments and more:

Polyneuropathy (17,901 reports)

Browse all side effects of Loperamide hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Polyneuropathy:

Polyneuropathy (905 drugs)

Browse all the conditions that are associated with Polyneuropathy:

Polyneuropathy (944 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on loperamide hydrochloride (the active ingredients of Loperamide hydrochloride) and Loperamide hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.