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Loperamide hydrochloride and Pyoderma gangrenosum - a phase IV clinical study of FDA data

Summary:

Pyoderma gangrenosum is reported as a side effect among people who take Loperamide hydrochloride (loperamide hydrochloride), especially for people who are female, 50-59 old, also take Flagyl, and have Inflammatory bowel disease.

The phase IV clinical study analyzes which people have Pyoderma gangrenosum when taking Loperamide hydrochloride. It is created by eHealthMe based on reports of 10,478 people who have side effects when taking Loperamide hydrochloride from the FDA, and is updated regularly.

What is Loperamide hydrochloride?

Loperamide hydrochloride has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 10,814 Loperamide hydrochloride users. Check the latest studies of Loperamide hydrochloride.

What is Pyoderma gangrenosum?

Pyoderma gangrenosum (ulcerating condition of skin that results in heaped borders with a typical appearance) is found to be associated with 305 drugs and 348 conditions by eHealthMe. Check the latest studies of Pyoderma gangrenosum.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

10,478 people reported to have side effects when taking Loperamide hydrochloride.
Among them, 11 people (0.1%) have Pyoderma gangrenosum.

Could Loperamide hydrochloride cause Pyoderma gangrenosum?

Among these 11 people:

What is the gender of people who have Pyoderma gangrenosum when taking Loperamide hydrochloride? *

  • female: 63.64 %
  • male: 36.36 %

What is the age of people who have Pyoderma gangrenosum when taking Loperamide hydrochloride? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 90.91 %
  • 60+: 9.09 %

What are other drugs people take besides Loperamide hydrochloride? *

  1. Flagyl: 10 people, 90.91%
  2. Pantoprazole: 8 people, 72.73%
  3. Xeljanz: 7 people, 63.64%
  4. Humira: 7 people, 63.64%
  5. Arava: 7 people, 63.64%
  6. Tofacitinib: 7 people, 63.64%
  7. Stelara: 7 people, 63.64%
  8. Celebrex: 7 people, 63.64%
  9. Cosentyx: 7 people, 63.64%
  10. Jardiance: 7 people, 63.64%

What are other side effects people have besides Pyoderma gangrenosum? *

  1. Small Intestinal Obstruction (blockage in small intestine): 7 people, 63.64%
  2. Joint Range Of Motion Decreased (disease of joint movement): 7 people, 63.64%
  3. Back Pain: 7 people, 63.64%
  4. Dactylitis (dactylitis or sausage digit is inflammation of an entire digit (a finger or toe), and can be painful): 7 people, 63.64%
  5. Depression: 7 people, 63.64%
  6. Drug Ineffective: 7 people, 63.64%
  7. Dry Eyes (lack of adequate tears): 7 people, 63.64%
  8. Eye Pruritus (eye itching): 7 people, 63.64%
  9. Gait Disturbance: 7 people, 63.64%
  10. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 63.64%

What are the existing conditions these people have? *

  1. Inflammatory Bowel Disease: 6 people, 54.55%
  2. Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 3 people, 27.27%
  3. Diabetes: 2 people, 18.18%
  4. Venous Thrombosis (blood clot (thrombus) that forms within a vein): 1 person, 9.09%
  5. Myocardial Ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased): 1 person, 9.09%
  6. Hypokalemia (low potassium): 1 person, 9.09%
  7. Hyperuricaemia (level of uric acid in the blood that is abnormally high): 1 person, 9.09%
  8. High Blood Pressure: 1 person, 9.09%
  9. Diabetic Retinopathy (damage to the retina caused by complications of diabetes): 1 person, 9.09%
  10. Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Loperamide hydrochloride and have Pyoderma gangrenosum?

- Check whether Pyoderma gangrenosum is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Loperamide hydrochloride:

Pyoderma gangrenosum treatments and more:

How severe was Pyoderma gangrenosum and when was it recovered:

Expand to all the drugs that have ingredients of loperamide hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Loperamide hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pyoderma gangrenosum:

Browse all the conditions that are associated with Pyoderma gangrenosum:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on loperamide hydrochloride (the active ingredients of Loperamide hydrochloride) and Loperamide hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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