Lopurin and Cogwheel rigidity - a phase IV clinical study of FDA data

Summary:

Cogwheel rigidity is reported as a side effect among people who take Lopurin (allopurinol), especially for people who are male, 60+ old, also take Sertraline, and have Parkinson's disease.

The phase IV clinical study analyzes which people have Cogwheel rigidity when taking Lopurin. It is created by eHealthMe based on reports of 188,140 people who have side effects when taking Lopurin from the FDA, and is updated regularly.

What is Lopurin?

Lopurin has active ingredients of allopurinol. It is often used in gout. eHealthMe is studying from 190,798 Lopurin users. Check the latest studies of Lopurin.

What is Cogwheel rigidity?

Cogwheel rigidity (tension in a muscle which gives way in little jerks when the muscle is stretched) is found to be associated with 157 drugs and 302 conditions by eHealthMe. Check the latest studies of Cogwheel rigidity.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

188,140 people reported to have side effects when taking Lopurin.
Among them, 20 people (0.01%) have Cogwheel rigidity.

Among these 20 people:

What is the gender of people who have Cogwheel rigidity when taking Lopurin? *

female: 5.26 %
male: 94.74 %

What is the age of people who have Cogwheel rigidity when taking Lopurin? *

What are other drugs people take besides Lopurin? *

Sertraline: 18 people, 90.00%
Tamsulosin: 17 people, 85.00%
Pantoprazole: 16 people, 80.00%
Vancomycin: 5 people, 25.00%
Carbidopa And Levodopa: 5 people, 25.00%
Zithromax: 1 person, 5.00%
Ciprofloxacin: 1 person, 5.00%
Hydrochlorothiazide: 1 person, 5.00%
Glycolax: 1 person, 5.00%
Fluconazole: 1 person, 5.00%

What are other side effects people have besides Cogwheel rigidity? *

Movement - Uncontrolled Or Slow: 19 people, 95.00%
Resting Tremor (an involuntary somewhat rhythmic, muscle contraction and relaxation during resting condition): 13 people, 65.00%
Tremor (trembling or shaking movements in one or more parts of your body): 8 people, 40.00%
Drug Level Increased: 5 people, 25.00%
Kidney Infection (Pyelonephritis): 2 people, 10.00%
Gait Disturbance: 1 person, 5.00%
Dry Mouth: 1 person, 5.00%
Dyskinesia (abnormality or impairment of voluntary movement): 1 person, 5.00%
Emotional Distress: 1 person, 5.00%
Enlarged Prostate: 1 person, 5.00%

What are the existing conditions these people have? *

Parkinson's Disease: 15 people, 75.00%
Urinary Tract Infection: 7 people, 35.00%
Klebsiella Infection: 5 people, 25.00%
Kidney Infection (Pyelonephritis): 4 people, 20.00%
Pneumonia Klebsiella (pneumonia caused by bacteria klebsiella): 2 people, 10.00%
Pathogen Resistance: 1 person, 5.00%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 1 person, 5.00%
Immunodeficiency Disorders: 1 person, 5.00%
High Blood Pressure: 1 person, 5.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Lopurin and have Cogwheel rigidity?

- Check whether Cogwheel rigidity is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lopurin:

Lopurin (190,798 reports)

Browse all side effects of Lopurin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cogwheel rigidity:

Cogwheel rigidity (157 drugs)

Browse all the conditions that are associated with Cogwheel rigidity:

Cogwheel rigidity (302 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on allopurinol (the active ingredients of Lopurin) and Lopurin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.