Loratadine and Rebound effect - a phase IV clinical study of FDA data

Summary:

Rebound effect is reported as a side effect among people who take Loratadine (loratadine), especially for people who are female, 60+ old, also take Vitamin K, and have Atrial fibrillation/flutter.

The phase IV clinical study analyzes which people have Rebound effect when taking Loratadine. It is created by eHealthMe based on reports of 53,991 people who have side effects when taking Loratadine from the FDA, and is updated regularly.

What is Loratadine?

Loratadine has active ingredients of loratadine. It is often used in allergies. eHealthMe is studying from 56,315 Loratadine users. Check the latest studies of Loratadine.

What is Rebound effect?

Rebound effect (take-back effect) is found to be associated with 368 drugs and 569 conditions by eHealthMe. Check the latest studies of Rebound effect.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

53,991 people reported to have side effects when taking Loratadine.
Among them, 19 people (0.04%) have Rebound effect.

Among these 19 people:

What is the gender of people who have Rebound effect when taking Loratadine? *

female: 73.68 %
male: 26.32 %

What is the age of people who have Rebound effect when taking Loratadine? *

What are other drugs people take besides Loratadine? *

What are other side effects people have besides Rebound effect? *

Drug Ineffective: 13 people, 68.42%
Haematoma (collection of blood outside the blood vessels): 6 people, 31.58%
Haemorrhage (bleeding): 6 people, 31.58%
Coagulation Time Prolonged: 6 people, 31.58%
Overdose: 6 people, 31.58%
Emotional Disorder: 5 people, 26.32%
Sepsis (a severe blood infection that can lead to organ failure and death): 5 people, 26.32%
Depression: 4 people, 21.05%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 4 people, 21.05%
The Flu (the flu is caused by an influenza virus): 4 people, 21.05%

What are the existing conditions these people have? *

Haemorrhage (bleeding): 6 people, 31.58%
Coagulation Time Prolonged: 6 people, 31.58%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 31.58%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 26.32%
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 4 people, 21.05%
Nasal Polyps (masses that develop in the lining of the nose): 4 people, 21.05%
Headache (pain in head): 4 people, 21.05%
Stress And Anxiety: 4 people, 21.05%
Emotional Disorder: 4 people, 21.05%
Urticaria Chronic (long lasting rash of round, red welts on the skin that itch intensely): 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

Do you take Loratadine and have Rebound effect?

- Check whether Rebound effect is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Loratadine:

Loratadine (56,315 reports)

Rebound effect treatments and more:

Rebound effect (8,859 reports)

Browse all side effects of Loratadine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Rebound effect:

Rebound effect (368 drugs)

Browse all the conditions that are associated with Rebound effect:

Rebound effect (569 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on loratadine (the active ingredients of Loratadine) and Loratadine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.