Loraz and Aortic valve replacement - a phase IV clinical study of FDA data

Summary:

Aortic valve replacement is reported as a side effect among people who take Loraz (lorazepam), especially for people who are female, 60+ old, have been taking the drug for 10+ years also take Aspirin, and have Diabetes.

The phase IV clinical study analyzes which people have Aortic valve replacement when taking Loraz. It is created by eHealthMe based on reports of 161,700 people who have side effects when taking Loraz from the FDA, and is updated regularly.

What is Loraz?

Loraz has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 165,695 Loraz users. Check the latest studies of Loraz.

What is Aortic valve replacement?

Aortic valve replacement is found to be associated with 190 drugs and 329 conditions by eHealthMe. Check the latest studies of Aortic valve replacement.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

161,700 people reported to have side effects when taking Loraz.
Among them, 13 people (0.01%) have Aortic valve replacement.

Could Loraz cause Aortic valve replacement?

Among these 13 people:

How long have people been on Loraz when they have Aortic valve replacement? *

What is the gender of people who have Aortic valve replacement when taking Loraz? *

female: 72.73 %
male: 27.27 %

What is the age of people who have Aortic valve replacement when taking Loraz? *

What are other drugs people take besides Loraz? *

What are other side effects people have besides Aortic valve replacement? *

Heart Attack: 5 people, 38.46%
Mitral Valve Incompetence (inefficient heart valve): 5 people, 38.46%
Angina Unstable (chest pain due to ischemia of the heart muscle- unstable): 4 people, 30.77%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 4 people, 30.77%
Cardiac Failure Congestive: 4 people, 30.77%
Cardiac Failure: 4 people, 30.77%
Cardiac Arrest: 3 people, 23.08%
Acute Kidney Failure: 2 people, 15.38%
Device Dislocation: 2 people, 15.38%
Overdose: 2 people, 15.38%

What are the existing conditions these people have? *

Diabetes: 3 people, 23.08%
Sleep Disorder: 1 person, 7.69%
Prostate Cancer: 1 person, 7.69%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 7.69%
Asthma: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Loraz and have Aortic valve replacement?

- Check whether Aortic valve replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Loraz:

Loraz (165,695 reports)

Browse all side effects of Loraz:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aortic valve replacement:

Aortic valve replacement (190 drugs)

Browse all the conditions that are associated with Aortic valve replacement:

Aortic valve replacement (329 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on lorazepam (the active ingredients of Loraz) and Loraz (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.