Loraz and Macule - a phase IV clinical study of FDA data

Summary:

Macule is reported as a side effect among people who take Loraz (lorazepam), especially for people who are female, 40-49 old, also take Paxil, and have Pain.

The phase IV clinical study analyzes which people have Macule when taking Loraz. It is created by eHealthMe based on reports of 161,700 people who have side effects when taking Loraz from the FDA, and is updated regularly.

What is Loraz?

Loraz has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 165,692 Loraz users. Check the latest studies of Loraz.

What is Macule?

Macule (a discoloured spot on the skin) is found to be associated with 303 drugs and 705 conditions by eHealthMe. Check the latest studies of Macule.

On Jun, 16, 2026

161,700 people reported to have side effects when taking Loraz.
Among them, 27 people (0.02%) have Macule.

Among these 27 people:

What is the gender of people who have Macule when taking Loraz? *

female: 75 %
male: 25 %

What is the age of people who have Macule when taking Loraz? *

What are other drugs people take besides Loraz? *

What are other side effects people have besides Macule? *

Pain: 21 people, 77.78%
Rashes (redness): 16 people, 59.26%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 16 people, 59.26%
High Blood Pressure: 15 people, 55.56%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 15 people, 55.56%
Joint Pain: 15 people, 55.56%
Hypoaesthesia (reduced sense of touch or sensation): 15 people, 55.56%
Osteomyelitis (infection of bone): 14 people, 51.85%
Osteonecrosis Of Jaw (death of bone of jaw): 14 people, 51.85%
Muscle Spasms (muscle contraction): 14 people, 51.85%

What are the existing conditions these people have? *

Pain: 5 people, 18.52%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 4 people, 14.81%
Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 4 people, 14.81%
Multiple Myeloma (cancer of the plasma cells): 3 people, 11.11%
Bone Lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries): 2 people, 7.41%
Sleep Disorder: 2 people, 7.41%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 7.41%
Renal Cell Carcinoma Stage Iv (stage iv renal cell cancer have cancer that has spread to other organs, such as the lungs, liver, bones, or brain, and may have spread to lymph nodes): 2 people, 7.41%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 7.41%
Upper Respiratory Tract Infection: 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

Do you take Loraz and have Macule?

- Check whether Macule is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Loraz:

Loraz (165,692 reports)

Macule treatments and more:

Macule (3,263 reports)

Browse all side effects of Loraz:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Macule:

Macule (303 drugs)

Browse all the conditions that are associated with Macule:

Macule (705 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on lorazepam (the active ingredients of Loraz) and Loraz (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.