Lorcet-hd and Mitral valve incompetence - a phase IV clinical study of FDA data

Summary:

Mitral valve incompetence is reported as a side effect among people who take Lorcet-hd (acetaminophen; hydrocodone bitartrate), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Vioxx, and have Neoplasm malignant.

The phase IV clinical study analyzes which people have Mitral valve incompetence when taking Lorcet-hd. It is created by eHealthMe based on reports of 2,140 people who have side effects when taking Lorcet-hd from the FDA, and is updated regularly.

What is Lorcet-hd?

Lorcet-hd has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 2,221 Lorcet-hd users. Check the latest studies of Lorcet-hd.

What is Mitral valve incompetence?

Mitral valve incompetence (inefficient heart valve) is found to be associated with 1,431 drugs and 1,280 conditions by eHealthMe. Check the latest studies of Mitral valve incompetence.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

2,140 people reported to have side effects when taking Lorcet-hd.
Among them, 37 people (1.73%) have Mitral valve incompetence.

Could Lorcet-hd cause Mitral valve incompetence?

Among these 37 people:

How long have people been on Lorcet-hd when they have Mitral valve incompetence? *

What is the gender of people who have Mitral valve incompetence when taking Lorcet-hd? *

female: 67.57 %
male: 32.43 %

What is the age of people who have Mitral valve incompetence when taking Lorcet-hd? *

What are other drugs people take besides Lorcet-hd? *

What are other side effects people have besides Mitral valve incompetence? *

Joint Pain: 24 people, 64.86%
Stress And Anxiety: 23 people, 62.16%
High Blood Pressure: 22 people, 59.46%
Dyspnea (difficult or laboured breathing): 22 people, 59.46%
Weakness: 21 people, 56.76%
Depression: 21 people, 56.76%
Hyperlipidaemia (presence of excess lipids in the blood): 20 people, 54.05%
Fainting (loss of consciousness and postural tone): 20 people, 54.05%
Headache (pain in head): 19 people, 51.35%
Fatigue (feeling of tiredness): 19 people, 51.35%

What are the existing conditions these people have? *

Lung Neoplasm (tumour of lung): 12 people, 32.43%
Metastases To Spine (cancer spreads to spine): 12 people, 32.43%
Calcium Deficiency (lack of calcium): 12 people, 32.43%
Neoplasm Malignant (cancer tumour): 12 people, 32.43%
High Blood Pressure: 5 people, 13.51%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 8.11%
Cardiac Disorder: 3 people, 8.11%
Gastric Ulcer (stomach ulcer): 3 people, 8.11%
High Blood Cholesterol: 3 people, 8.11%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 3 people, 8.11%

* Approximation only. Some reports may have incomplete information.

Do you take Lorcet-hd and have Mitral valve incompetence?

- Check whether Mitral valve incompetence is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lorcet-hd:

Lorcet-hd (2,221 reports)

Mitral valve incompetence treatments and more:

Mitral valve incompetence (20,804 reports)

How severe was Mitral valve incompetence and when was it recovered:

Mitral valve incompetence in Lorcet-hd

Expand to all the drugs that have ingredients of acetaminophen; hydrocodone bitartrate:

Mitral valve incompetence and drugs with ingredients of acetaminophen; hydrocodone bitartrate (1,060 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lorcet-hd:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mitral valve incompetence:

Mitral valve incompetence (1,431 drugs)

Browse all the conditions that are associated with Mitral valve incompetence:

Mitral valve incompetence (1,280 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; hydrocodone bitartrate (the active ingredients of Lorcet-hd) and Lorcet-hd (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.