Lortab and Injection site urticaria - a phase IV clinical study of FDA data

Summary:

Injection site urticaria is reported as a side effect among people who take Lortab (acetaminophen; hydrocodone bitartrate), especially for people who are female, 50-59 old, also take Humira, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Injection site urticaria when taking Lortab. It is created by eHealthMe based on reports of 29,547 people who have side effects when taking Lortab from the FDA, and is updated regularly.

What is Lortab?

Lortab has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 31,285 Lortab users. Check the latest studies of Lortab.

What is Injection site urticaria?

Injection site urticaria (rash of round, red welts on the skin at injection site) is found to be associated with 557 drugs and 612 conditions by eHealthMe. Check the latest studies of Injection site urticaria.

On Jul, 12, 2026

29,547 people reported to have side effects when taking Lortab.
Among them, 28 people (0.09%) have Injection site urticaria.

Could Lortab cause Injection site urticaria?

Among these 28 people:

What is the gender of people who have Injection site urticaria when taking Lortab? *

female: 82.14 %
male: 17.86 %

What is the age of people who have Injection site urticaria when taking Lortab? *

What are other drugs people take besides Lortab? *

What are other side effects people have besides Injection site urticaria? *

Injection Site Pain: 11 people, 39.29%
Injection Site Erythema (redness at injection site): 6 people, 21.43%
Injection Site Discoloration: 4 people, 14.29%
Injection Site Pruritus (severe itching at injection site): 4 people, 14.29%
Fatigue (feeling of tiredness): 3 people, 10.71%
Injection Site Warmth: 3 people, 10.71%
The Flu (the flu is caused by an influenza virus): 3 people, 10.71%
Injection Site Bruising: 2 people, 7.14%
Pain In Extremity: 2 people, 7.14%
Pneumonia: 2 people, 7.14%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 28.57%
Depression: 5 people, 17.86%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 14.29%
Ankylosing Spondylitis (type of arthritis affecting the spine): 3 people, 10.71%
Migraine (headache): 3 people, 10.71%
Urticaria (rash of round, red welts on the skin that itch intensely): 2 people, 7.14%
Muscle Aches (muscle pain): 2 people, 7.14%
Bartter's Syndrome (inherited defect in the thick ascending limb of the loop of henle): 2 people, 7.14%
Bipolar Disorder (mood disorder): 2 people, 7.14%
High Blood Pressure: 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Lortab and have Injection site urticaria?

- Check whether Injection site urticaria is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lortab:

Lortab (31,285 reports)

Injection site urticaria treatments and more:

Injection site urticaria (21,717 reports)

How severe was Injection site urticaria and when was it recovered:

Injection site urticaria in Lortab

Expand to all the drugs that have ingredients of acetaminophen; hydrocodone bitartrate:

Injection site urticaria and drugs with ingredients of acetaminophen; hydrocodone bitartrate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lortab:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Injection site urticaria:

Injection site urticaria (557 drugs)

Browse all the conditions that are associated with Injection site urticaria:

Injection site urticaria (612 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; hydrocodone bitartrate (the active ingredients of Lortab) and Lortab (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.