Lortab and Skin tightness - a phase IV clinical study of FDA data

Summary:

Skin tightness is reported as a side effect among people who take Lortab (acetaminophen; hydrocodone bitartrate), especially for people who are female, 30-39 old, also take Magnevist, and have Nuclear magnetic resonance imaging brain.

The phase IV clinical study analyzes which people have Skin tightness when taking Lortab. It is created by eHealthMe based on reports of 29,547 people who have side effects when taking Lortab from the FDA, and is updated regularly.

What is Lortab?

Lortab has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 31,285 Lortab users. Check the latest studies of Lortab.

What is Skin tightness?

Skin tightness is found to be associated with 609 drugs and 607 conditions by eHealthMe. Check the latest studies of Skin tightness.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

29,547 people reported to have side effects when taking Lortab.
Among them, 14 people (0.05%) have Skin tightness.

Among these 14 people:

What is the gender of people who have Skin tightness when taking Lortab? *

female: 78.57 %
male: 21.43 %

What is the age of people who have Skin tightness when taking Lortab? *

What are other drugs people take besides Lortab? *

What are other side effects people have besides Skin tightness? *

Oedema Peripheral (superficial swelling): 12 people, 85.71%
Nephrogenic Systemic Fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease): 11 people, 78.57%
Skin Induration (an abnormally hard spot or area on the skin): 11 people, 78.57%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 10 people, 71.43%
Gait Disturbance: 10 people, 71.43%
Pain In Extremity: 9 people, 64.29%
Emotional Distress: 9 people, 64.29%
Stress And Anxiety: 9 people, 64.29%
Skin Hypertrophy (skin cells enlarges): 9 people, 64.29%
Anhedonia (inability to experience pleasure from activities usually found enjoyable): 9 people, 64.29%

What are the existing conditions these people have? *

Nuclear Magnetic Resonance Imaging Brain: 11 people, 78.57%
High Blood Pressure: 9 people, 64.29%
Anaemia (lack of blood): 9 people, 64.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 57.14%
Bloody Peritoneal Effluent: 7 people, 50.00%
Wheezing (a high-pitched whistling sound made while you breath): 7 people, 50.00%
Stress And Anxiety: 7 people, 50.00%
Nuclear Magnetic Resonance Imaging Abdominal: 6 people, 42.86%
Urticaria (rash of round, red welts on the skin that itch intensely): 2 people, 14.29%
Diabetes: 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

Do you take Lortab and have Skin tightness?

- Check whether Skin tightness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lortab:

Lortab (31,285 reports)

Skin tightness treatments and more:

Skin tightness (5,694 reports)

How severe was Skin tightness and when was it recovered:

Skin tightness in Lortab

Expand to all the drugs that have ingredients of acetaminophen; hydrocodone bitartrate:

Skin tightness and drugs with ingredients of acetaminophen; hydrocodone bitartrate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lortab:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Skin tightness:

Skin tightness (609 drugs)

Browse all the conditions that are associated with Skin tightness:

Skin tightness (607 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; hydrocodone bitartrate (the active ingredients of Lortab) and Lortab (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.