Loryna and Fatigue aggravated - a phase IV clinical study of FDA data

Summary:

Fatigue aggravated is reported as a side effect among people who take Loryna (drospirenone; ethinyl estradiol), especially for people who are female, 30-39 old, have been taking the drug for < 1 month also take Biotin, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Fatigue aggravated when taking Loryna. It is created by eHealthMe based on reports of 336 people who have side effects when taking Loryna from the FDA, and is updated regularly.

What is Loryna?

Loryna has active ingredients of drospirenone; ethinyl estradiol. It is often used in birth control. eHealthMe is studying from 388 Loryna users. Check the latest studies of Loryna.

What is Fatigue aggravated?

Fatigue aggravated (feeling of tiredness) is found to be associated with 3,115 drugs and 1,115 conditions by eHealthMe. Check the latest studies of Fatigue aggravated.

On Jul, 18, 2026

336 people reported to have side effects when taking Loryna.
Among them, 22 people (6.55%) have Fatigue aggravated.

Among these 22 people:

How long have people been on Loryna when they have Fatigue aggravated? *

What is the gender of people who have Fatigue aggravated when taking Loryna? *

female: 100 %
male: 0.0 %

What is the age of people who have Fatigue aggravated when taking Loryna? *

What are other drugs people take besides Loryna? *

What are other side effects people have besides Fatigue aggravated? *

Mood Swings (an extreme or rapid change in mood): 5 people, 22.73%
Dizziness: 5 people, 22.73%
Feeling Abnormal: 4 people, 18.18%
Depression: 4 people, 18.18%
Nausea And Vomiting: 4 people, 18.18%
Abdominal Discomfort: 3 people, 13.64%
Oropharyngeal Pain: 3 people, 13.64%
Headache (pain in head): 3 people, 13.64%
Insomnia (sleeplessness): 3 people, 13.64%
Migraine (headache): 3 people, 13.64%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 31.82%
Depression: 3 people, 13.64%
Acne (skin problems that cause pimples): 3 people, 13.64%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 9.09%
Stress And Anxiety: 1 person, 4.55%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 4.55%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 4.55%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 1 person, 4.55%
Drowsiness: 1 person, 4.55%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Loryna and have Fatigue aggravated?

- Check whether Fatigue aggravated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Loryna:

Loryna (388 reports)

Fatigue aggravated treatments and more:

Fatigue aggravated (252 reports)

How severe was Fatigue aggravated and when was it recovered:

Fatigue aggravated in Loryna

Expand to all the drugs that have ingredients of drospirenone; ethinyl estradiol:

Fatigue aggravated and drugs with ingredients of drospirenone; ethinyl estradiol (1,753 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Loryna:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fatigue aggravated:

Fatigue aggravated (3,116 drugs)

Browse all the conditions that are associated with Fatigue aggravated:

Fatigue aggravated (1,115 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on drospirenone; ethinyl estradiol (the active ingredients of Loryna) and Loryna (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.