Losartan and Brain death - a phase IV clinical study of FDA data

Summary:

Brain death is reported as a side effect among people who take Losartan (losartan potassium), especially for people who are male, 60+ old, also take Spironolactone, and have Atrial fibrillation/flutter.

The study is created by eHealthMe based on reports of 170,768 people who have side effects when taking Losartan from the FDA, and is updated regularly.

What is Losartan?

Losartan has active ingredients of losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 177,692 Losartan users. Check the latest studies of Losartan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

170,768 people reported to have side effects when taking Losartan.
Among them, 46 people (0.03%) died.

Among these 46 people:

What is the gender of people who died when taking Losartan? *

female: 37.78 %
male: 62.22 %

What is the age of people who died when taking Losartan? *

What are other drugs people take besides Losartan? *

What are other side effects people have before they died? *

Drug Ineffective: 8 people, 17.39%
Cardiac Arrest: 7 people, 15.22%
Heart Attack: 6 people, 13.04%
Hypoxic-Ischaemic Encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total): 6 people, 13.04%
Cerebral Haemorrhage (bleeding within the brain): 6 people, 13.04%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 6 people, 13.04%
Loss Of Consciousness: 5 people, 10.87%
Haemothorax (collection of blood in the pleural space (the space between the lungs and the walls of the chest)): 5 people, 10.87%
Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 5 people, 10.87%
Systemic Inflammatory Response Syndrome (an inflammatory state affecting the whole body, frequently a response of the immune system to infection): 5 people, 10.87%

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 8 people, 17.39%
Hypotension (abnormally low blood pressure): 6 people, 13.04%
Bacterial Infection: 5 people, 10.87%
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin): 5 people, 10.87%
Congestive Cardiomyopathy (weakening of heart muscle): 4 people, 8.70%
Pain: 4 people, 8.70%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 8.70%
Chronic Kidney Disease: 4 people, 8.70%
Hyperkalemia (damage to or disease of the kidney): 3 people, 6.52%
Stress And Anxiety: 2 people, 4.35%

* Approximation only. Some reports may have incomplete information.

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Losartan:

Losartan (177,692 reports)

Expand to all the drugs that have ingredients of losartan potassium:

Brain death and drugs with ingredients of losartan potassium (54 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Losartan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Brain death:

Brain death (315 drugs)

Browse all the conditions that are associated with Brain death:

Brain death (489 conditions)

Related publications that referenced our studies

Lai SW, Lin HF, Lin CL, Liao KF, "No association between losartan use and acute pancreatitis in hypertensive patients", Eur J Hosp Pharm, 2017 Mar .
Lai SW, Lin HF, Lin CL, Liao KF, "No association between losartan use and acute pancreatitis in hypertensive patients", Eur J Hosp Pharm, 2017 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on losartan potassium (the active ingredients of Losartan) and Losartan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.