Lotrel and Joint effusion - a phase IV clinical study of FDA data

Summary:

Joint effusion is reported as a side effect among people who take Lotrel (amlodipine besylate; benazepril hydrochloride), especially for people who are male, 60+ old, have been taking the drug for 2 - 5 years also take Lexapro, and have Sinusitis.

The phase IV clinical study analyzes which people have Joint effusion when taking Lotrel. It is created by eHealthMe based on reports of 13,000 people who have side effects when taking Lotrel from the FDA, and is updated regularly.

What is Lotrel?

Lotrel has active ingredients of amlodipine besylate; benazepril hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 13,571 Lotrel users. Check the latest studies of Lotrel.

What is Joint effusion?

Joint effusion (presence of extra fluid in joint covering) is found to be associated with 872 drugs and 750 conditions by eHealthMe. Check the latest studies of Joint effusion.

On Jul, 08, 2026

13,000 people reported to have side effects when taking Lotrel.
Among them, 13 people (0.1%) have Joint effusion.

Among these 13 people:

How long have people been on Lotrel when they have Joint effusion? *

What is the gender of people who have Joint effusion when taking Lotrel? *

female: 30.77 %
male: 69.23 %

What is the age of people who have Joint effusion when taking Lotrel? *

What are other drugs people take besides Lotrel? *

What are other side effects people have besides Joint effusion? *

Joint Pain: 8 people, 61.54%
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder): 7 people, 53.85%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 6 people, 46.15%
Depression: 5 people, 38.46%
Pain In Extremity: 5 people, 38.46%
Tendonitis (a condition that causes pain and swelling of tendons): 5 people, 38.46%
Tendon Rupture (tear of tendon): 5 people, 38.46%
Fall: 5 people, 38.46%
Spinal Osteoarthritis (joint cartilage loss in spine): 4 people, 30.77%
Pain: 4 people, 30.77%

What are the existing conditions these people have? *

Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 3 people, 23.08%
Muscle Spasms (muscle contraction): 3 people, 23.08%
Sinusitis (inflammation of sinus): 3 people, 23.08%
Bone Lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries): 2 people, 15.38%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 2 people, 15.38%
Multiple Myeloma (cancer of the plasma cells): 2 people, 15.38%
Upper Respiratory Tract Infection: 2 people, 15.38%
Pain: 2 people, 15.38%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 15.38%
Osteoporosis (bones weak and more likely to break): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Lotrel and have Joint effusion?

- Check whether Joint effusion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lotrel:

Lotrel (13,571 reports)

Joint effusion treatments and more:

Joint effusion (9,947 reports)

How severe was Joint effusion and when was it recovered:

Joint effusion in Lotrel

Expand to all the drugs that have ingredients of amlodipine besylate; benazepril hydrochloride:

Joint effusion and drugs with ingredients of amlodipine besylate; benazepril hydrochloride

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lotrel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint effusion:

Joint effusion (872 drugs)

Browse all the conditions that are associated with Joint effusion:

Joint effusion (750 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on amlodipine besylate; benazepril hydrochloride (the active ingredients of Lotrel) and Lotrel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.