Lotrel and Personality change - a phase IV clinical study of FDA data

Summary:

Personality change is reported as a side effect among people who take Lotrel (amlodipine besylate; benazepril hydrochloride), especially for people who are female, 60+ old, also take Chantix, and have Quit smoking.

The phase IV clinical study analyzes which people have Personality change when taking Lotrel. It is created by eHealthMe based on reports of 13,000 people who have side effects when taking Lotrel from the FDA, and is updated regularly.

What is Lotrel?

Lotrel has active ingredients of amlodipine besylate; benazepril hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 13,571 Lotrel users. Check the latest studies of Lotrel.

What is Personality change?

Personality change is found to be associated with 726 drugs and 946 conditions by eHealthMe. Check the latest studies of Personality change.

On Jul, 05, 2026

13,000 people reported to have side effects when taking Lotrel.
Among them, 17 people (0.13%) have Personality change.

Among these 17 people:

What is the gender of people who have Personality change when taking Lotrel? *

female: 52.94 %
male: 47.06 %

What is the age of people who have Personality change when taking Lotrel? *

What are other drugs people take besides Lotrel? *

What are other side effects people have besides Personality change? *

Hallucinations (sensations that appear real but are created by your mind): 5 people, 29.41%
Grip Strength Decreased: 5 people, 29.41%
Weakness: 5 people, 29.41%
Blood Glucose Increased: 5 people, 29.41%
Fall: 5 people, 29.41%
Blood Iron Decreased: 5 people, 29.41%
Speech Impairment (Adult) (inability to speak (adult)): 5 people, 29.41%
Blood Phosphorus Increased: 5 people, 29.41%
Blood Testosterone Decreased: 5 people, 29.41%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 5 people, 29.41%

What are the existing conditions these people have? *

Quit Smoking: 6 people, 35.29%
Asthma: 5 people, 29.41%
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 3 people, 17.65%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 11.76%
Gait Disturbance: 2 people, 11.76%
Ankylosing Spondylitis (type of arthritis affecting the spine): 2 people, 11.76%
Neuropathy Peripheral (surface nerve damage): 1 person, 5.88%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 1 person, 5.88%
Diabetes: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Lotrel and have Personality change?

- Check whether Personality change is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lotrel:

Lotrel (13,571 reports)

Personality change treatments and more:

Personality change (11,729 reports)

How severe was Personality change and when was it recovered:

Personality change in Lotrel

Expand to all the drugs that have ingredients of amlodipine besylate; benazepril hydrochloride:

Personality change and drugs with ingredients of amlodipine besylate; benazepril hydrochloride

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lotrel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Personality change:

Personality change (726 drugs)

Browse all the conditions that are associated with Personality change:

Personality change (946 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on amlodipine besylate; benazepril hydrochloride (the active ingredients of Lotrel) and Lotrel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.