Lotronex and Anhedonia - a phase IV clinical study of FDA data

Summary:

Anhedonia is reported as a side effect among people who take Lotronex (alosetron hydrochloride), especially for people who are male, 50-59 old, have been taking the drug for 1 - 6 months also take Lasix,.

The phase IV clinical study analyzes which people have Anhedonia when taking Lotronex. It is created by eHealthMe based on reports of 6,819 people who have side effects when taking Lotronex from the FDA, and is updated regularly.

What is Lotronex?

Lotronex has active ingredients of alosetron hydrochloride. It is often used in irritable bowel syndrome. eHealthMe is studying from 6,841 Lotronex users. Check the latest studies of Lotronex.

What is Anhedonia?

Anhedonia (inability to experience pleasure from activities usually found enjoyable) is found to be associated with 1,523 drugs and 1,267 conditions by eHealthMe. Check the latest studies of Anhedonia.

On Feb, 11, 2026

6,819 people reported to have side effects when taking Lotronex.
Among them, 43 people (0.63%) have Anhedonia.

Among these 43 people:

How long have people been on Lotronex when they have Anhedonia? *

What is the gender of people who have Anhedonia when taking Lotronex? *

female: 50 %
male: 50 %

What is the age of people who have Anhedonia when taking Lotronex? *

What are other drugs people take besides Lotronex? *

What are other side effects people have besides Anhedonia? *

Constipation: 19 people, 44.19%
Blood In Stool: 15 people, 34.88%
Stress And Anxiety: 11 people, 25.58%
Injury: 11 people, 25.58%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 6 people, 13.95%
Nausea (feeling of having an urge to vomit): 6 people, 13.95%
Abdominal Pain Lower: 5 people, 11.63%
Diarrhea Haemorrhagic: 4 people, 9.30%
Decreased Activity: 4 people, 9.30%
Colon Adenoma (non cancerous epithelial colon tumour having a glandular origin and structure): 3 people, 6.98%

* Approximation only. Some reports may have incomplete information.

Do you take Lotronex and have Anhedonia?

- Check whether Anhedonia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lotronex:

Lotronex (6,841 reports)

Anhedonia treatments and more:

Anhedonia (51,942 reports)

Browse all side effects of Lotronex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Anhedonia:

Anhedonia (1,523 drugs)

Browse all the conditions that are associated with Anhedonia:

Anhedonia (1,267 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on alosetron hydrochloride (the active ingredients of Lotronex) and Lotronex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.