Loxapine and Cholestasis - a phase IV clinical study of FDA data

Summary:

Cholestasis is reported as a side effect among people who take Loxapine (loxapine succinate), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Pantoprazole, and have Stress and anxiety.

The phase IV clinical study analyzes which people have Cholestasis when taking Loxapine. It is created by eHealthMe based on reports of 5,005 people who have side effects when taking Loxapine from the FDA, and is updated regularly.

What is Loxapine?

Loxapine has active ingredients of loxapine succinate. eHealthMe is studying from 5,039 Loxapine users. Check the latest studies of Loxapine.

What is Cholestasis?

Cholestasis (a condition where bile cannot flow from the liver to the duodenum) is found to be associated with 1,034 drugs and 1,810 conditions by eHealthMe. Check the latest studies of Cholestasis.

On Jul, 20, 2026

5,005 people reported to have side effects when taking Loxapine.
Among them, 61 people (1.22%) have Cholestasis.

Among these 61 people:

How long have people been on Loxapine when they have Cholestasis? *

What is the gender of people who have Cholestasis when taking Loxapine? *

female: 85.45 %
male: 14.55 %

What is the age of people who have Cholestasis when taking Loxapine? *

What are other drugs people take besides Loxapine? *

Pantoprazole: 11 people, 18.03%
Zopiclone: 10 people, 16.39%
Abilify: 9 people, 14.75%
Valium: 9 people, 14.75%
Diltiazem Hydrochloride: 8 people, 13.11%
Diazepam: 8 people, 13.11%
Aripiprazole: 8 people, 13.11%
Zoloft: 7 people, 11.48%
Letrozole: 7 people, 11.48%
Zoladex: 7 people, 11.48%

What are other side effects people have besides Cholestasis? *

Hepatocellular Injury (liver injury): 34 people, 55.74%
Cholangitis Sclerosing (infection and obstruction of bile duct): 7 people, 11.48%
Cytolytic Hepatitis (dissolution or destruction of a liver cell): 4 people, 6.56%
Weakness: 2 people, 3.28%
Nausea (feeling of having an urge to vomit): 2 people, 3.28%
Blood Alkaline Phosphatase Increased: 2 people, 3.28%
Blood Bilirubin Increased: 2 people, 3.28%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 2 people, 3.28%
Ocular Icterus (presence of jaundice seen in the sclera of the eye): 1 person, 1.64%
Gamma-Glutamyltransferase Increased: 1 person, 1.64%

What are the existing conditions these people have? *

Stress And Anxiety: 22 people, 36.07%
Psychotic Disorder: 12 people, 19.67%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 11 people, 18.03%
Diabetes: 11 people, 18.03%
Gastric Ulcer (stomach ulcer): 11 people, 18.03%
High Blood Cholesterol: 11 people, 18.03%
High Blood Pressure: 11 people, 18.03%
Insomnia (sleeplessness): 10 people, 16.39%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 10 people, 16.39%
Depression: 10 people, 16.39%

* Approximation only. Some reports may have incomplete information.

Do you take Loxapine and have Cholestasis?

- Check whether Cholestasis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Loxapine:

Loxapine (5,039 reports)

Cholestasis treatments and more:

Cholestasis (23,731 reports)

Browse all side effects of Loxapine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cholestasis:

Cholestasis (1,034 drugs)

Browse all the conditions that are associated with Cholestasis:

Cholestasis (1,810 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on loxapine succinate (the active ingredients of Loxapine) and Loxapine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.