Lupron depot and Menopause - a phase IV clinical study of FDA data

Summary:

Menopause is reported as a side effect among people who take Lupron depot (leuprolide acetate), especially for people who are 30-39 old, have been taking the drug for 1 - 6 months also take Omega 3, and have Uterine leiomyoma.

The phase IV clinical study analyzes which people have Menopause when taking Lupron depot. It is created by eHealthMe based on reports of 26,734 people who have side effects when taking Lupron depot from the FDA, and is updated regularly.

What is Lupron depot?

Lupron depot has active ingredients of leuprolide acetate. It is often used in endometriosis. eHealthMe is studying from 27,037 Lupron depot users. Check the latest studies of Lupron depot.

What is Menopause?

Menopause (end of monthly cycles in women) is found to be associated with 400 drugs and 488 conditions by eHealthMe. Check the latest studies of Menopause.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 18, 2026

26,734 people reported to have side effects when taking Lupron depot.
Among them, 35 people (0.13%) have Menopause.

Among these 35 people:

How long have people been on Lupron depot when they have Menopause? *

What is the age of people who have Menopause when taking Lupron depot? *

What are other drugs people take besides Lupron depot? *

What are other side effects people have besides Menopause? *

Pain: 10 people, 28.57%
Hot Flush (sudden feelings of heat): 9 people, 25.71%
Mood Swings (an extreme or rapid change in mood): 4 people, 11.43%
Irritability: 3 people, 8.57%
Night Sweats (sweating in night): 3 people, 8.57%
Abdominal Adhesions (inflammation of abdomen): 2 people, 5.71%
Breakthrough Pain: 2 people, 5.71%
Joint Pain: 2 people, 5.71%
Muscle Aches (muscle pain): 2 people, 5.71%
Drug Ineffective: 2 people, 5.71%

What are the existing conditions these people have? *

Uterine Leiomyoma (uterine benign tumour derived from smooth muscle): 2 people, 5.71%
Premenstrual Dysphoric Disorder: 1 person, 2.86%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 1 person, 2.86%
Breast Cancer Metastatic: 1 person, 2.86%

* Approximation only. Some reports may have incomplete information.

Do you take Lupron depot and have Menopause?

- Check whether Menopause is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lupron depot:

Lupron depot (27,037 reports)

Menopause treatments and more:

Menopause (14,552 reports)

Browse all side effects of Lupron depot:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Menopause:

Menopause (400 drugs)

Browse all the conditions that are associated with Menopause:

Menopause (488 conditions)

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on leuprolide acetate (the active ingredients of Lupron depot) and Lupron depot (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.