Macitentan and Underactive thyroid - a phase IV clinical study of FDA data

Summary:

Underactive thyroid is reported as a side effect among people who take Macitentan (macitentan), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Ondansetron, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Underactive thyroid when taking Macitentan. It is created by eHealthMe based on reports of 7,368 people who have side effects when taking Macitentan from the FDA, and is updated regularly.

What is Macitentan?

Macitentan has active ingredients of macitentan. eHealthMe is studying from 7,371 Macitentan users. Check the latest studies of Macitentan.

What is Underactive thyroid?

Underactive thyroid is found to be associated with 2,720 drugs and 2,644 conditions by eHealthMe. Check the latest studies of Underactive thyroid.

On Jun, 14, 2026

7,368 people reported to have side effects when taking Macitentan.
Among them, 15 people (0.2%) have Underactive thyroid.

Could Macitentan cause Underactive thyroid?

Among these 15 people:

How long have people been on Macitentan when they have Underactive thyroid? *

What is the gender of people who have Underactive thyroid when taking Macitentan? *

female: 86.67 %
male: 13.33 %

What is the age of people who have Underactive thyroid when taking Macitentan? *

What are other drugs people take besides Macitentan? *

What are other side effects people have besides Underactive thyroid? *

Weight Decreased: 6 people, 40.00%
Hypotension (abnormally low blood pressure): 5 people, 33.33%
Dyspnea (difficult or laboured breathing): 5 people, 33.33%
Headache (pain in head): 4 people, 26.67%
Urinary Tract Infection: 4 people, 26.67%
Dizziness: 4 people, 26.67%
Abdominal Pain Upper: 4 people, 26.67%
Back Pain: 3 people, 20.00%
Fatigue (feeling of tiredness): 3 people, 20.00%
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 3 people, 20.00%

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 12 people, 80.00%
Wheezing (a high-pitched whistling sound made while you breath): 3 people, 20.00%
Fever: 3 people, 20.00%
Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 3 people, 20.00%
Asthma: 3 people, 20.00%
Pain: 3 people, 20.00%
Nausea And Vomiting: 3 people, 20.00%
Nausea (feeling of having an urge to vomit): 3 people, 20.00%
Migraine (headache): 3 people, 20.00%
Depression: 3 people, 20.00%

* Approximation only. Some reports may have incomplete information.

Do you take Macitentan and have Underactive thyroid?

- Check whether Underactive thyroid is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Macitentan:

Macitentan (7,371 reports)

Browse all side effects of Macitentan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Underactive thyroid:

Underactive thyroid (2,720 drugs)

Browse all the conditions that are associated with Underactive thyroid:

Underactive thyroid (2,644 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on macitentan (the active ingredients of Macitentan) and Macitentan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.