Macrobid and Bile duct stenosis - a phase IV clinical study of FDA data

Summary:

Bile duct stenosis is reported as a side effect among people who take Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline), especially for people who are female, 60+ old, also take Flonase, and have Calcium deficiency.

The phase IV clinical study analyzes which people have Bile duct stenosis when taking Macrobid. It is created by eHealthMe based on reports of 8,335 people who have side effects when taking Macrobid from the FDA, and is updated regularly.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

What is Bile duct stenosis?

Bile duct stenosis (abnormal narrowing of the common bile duct) is found to be associated with 255 drugs and 355 conditions by eHealthMe. Check the latest studies of Bile duct stenosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

8,335 people reported to have side effects when taking Macrobid.
Among them, 40 people (0.48%) have Bile duct stenosis.

Could Macrobid cause Bile duct stenosis?

Among these 40 people:

What is the gender of people who have Bile duct stenosis when taking Macrobid? *

female: 100 %
male: 0.0 %

What is the age of people who have Bile duct stenosis when taking Macrobid? *

What are other drugs people take besides Macrobid? *

What are other side effects people have besides Bile duct stenosis? *

Weakness: 36 people, 90.00%
High Blood Pressure: 34 people, 85.00%
Fatigue (feeling of tiredness): 32 people, 80.00%
Pain: 28 people, 70.00%
Back Pain: 28 people, 70.00%
Dyspnea (difficult or laboured breathing): 27 people, 67.50%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 26 people, 65.00%
Emotional Distress: 26 people, 65.00%
Joint Pain: 26 people, 65.00%
Depression: 26 people, 65.00%

What are the existing conditions these people have? *

Neoplasm Malignant (cancer tumour): 25 people, 62.50%
Metastases To Spine (cancer spreads to spine): 25 people, 62.50%
Calcium Deficiency (lack of calcium): 25 people, 62.50%
Lung Neoplasm (tumour of lung): 24 people, 60.00%
Hyperlipidaemia (presence of excess lipids in the blood): 11 people, 27.50%
Metastases To Bone (cancer spreads to bone): 2 people, 5.00%
Breast Cancer: 2 people, 5.00%
Trigeminal Neuralgia (a painful condition of the nerve responsible for most facial sensation): 1 person, 2.50%
Pulmonary Mass: 1 person, 2.50%
Pain: 1 person, 2.50%

* Approximation only. Some reports may have incomplete information.

Do you take Macrobid and have Bile duct stenosis?

- Check whether Bile duct stenosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Macrobid:

Macrobid (9,215 reports)

Bile duct stenosis treatments and more:

Bile duct stenosis (1,624 reports)

How severe was Bile duct stenosis and when was it recovered:

Bile duct stenosis in Macrobid

Expand to all the drugs that have ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline:

Bile duct stenosis and drugs with ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Macrobid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bile duct stenosis:

Bile duct stenosis (255 drugs)

Browse all the conditions that are associated with Bile duct stenosis:

Bile duct stenosis (355 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on nitrofurantoin; nitrofurantoin, macrocrystalline (the active ingredients of Macrobid) and Macrobid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.