Macrobid and Coma - a phase IV clinical study of FDA data

Summary:

Coma is reported as a side effect among people who take Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Celebrex, and have Depression.

The phase IV clinical study analyzes which people have Coma when taking Macrobid. It is created by eHealthMe based on reports of 8,335 people who have side effects when taking Macrobid from the FDA, and is updated regularly.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

What is Coma?

Coma (state of unconsciousness lasting more than six hours) is found to be associated with 2,825 drugs and 3,206 conditions by eHealthMe. Check the latest studies of Coma.

On May, 01, 2026

8,335 people reported to have side effects when taking Macrobid.
Among them, 32 people (0.38%) have Coma.

Among these 32 people:

How long have people been on Macrobid when they have Coma? *

What is the gender of people who have Coma when taking Macrobid? *

female: 87.5 %
male: 12.5 %

What is the age of people who have Coma when taking Macrobid? *

What are other drugs people take besides Macrobid? *

What are other side effects people have besides Coma? *

Stress And Anxiety: 14 people, 43.75%
Pain: 13 people, 40.62%
Haemorrhage (bleeding): 12 people, 37.50%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 12 people, 37.50%
Dizziness: 12 people, 37.50%
High Blood Pressure: 12 people, 37.50%
Insomnia (sleeplessness): 11 people, 34.38%
Anaemia (lack of blood): 11 people, 34.38%
Arrhythmias (irregular heartbeat): 11 people, 34.38%
Hypoaesthesia (reduced sense of touch or sensation): 11 people, 34.38%

What are the existing conditions these people have? *

Depression: 14 people, 43.75%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 10 people, 31.25%
Metastases To Bone (cancer spreads to bone): 8 people, 25.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 12.50%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 6.25%
Insomnia (sleeplessness): 2 people, 6.25%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 6.25%
Cough: 2 people, 6.25%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 6.25%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Macrobid and have Coma?

- Check whether Coma is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Macrobid:

Macrobid (9,215 reports)

Coma treatments and more:

Coma (57,420 reports)

How severe was Coma and when was it recovered:

Coma in Macrobid

Expand to all the drugs that have ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline:

Coma and drugs with ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline (51 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Macrobid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Coma:

Coma (2,825 drugs)

Browse all the conditions that are associated with Coma:

Coma (3,206 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on nitrofurantoin; nitrofurantoin, macrocrystalline (the active ingredients of Macrobid) and Macrobid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.