Macrobid and Hepatic failure - a phase IV clinical study of FDA data

Summary:

Hepatic failure is reported as a side effect among people who take Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Levaquin, and have Hyperlipidaemia.

The phase IV clinical study analyzes which people have Hepatic failure when taking Macrobid. It is created by eHealthMe based on reports of 8,335 people who have side effects when taking Macrobid from the FDA, and is updated regularly.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

What is Hepatic failure?

Hepatic failure (liver failure) is found to be associated with 1,540 drugs and 1,892 conditions by eHealthMe. Check the latest studies of Hepatic failure.

On Jul, 20, 2026

8,335 people reported to have side effects when taking Macrobid.
Among them, 49 people (0.59%) have Hepatic failure.

Among these 49 people:

How long have people been on Macrobid when they have Hepatic failure? *

What is the gender of people who have Hepatic failure when taking Macrobid? *

female: 83.67 %
male: 16.33 %

What is the age of people who have Hepatic failure when taking Macrobid? *

What are other drugs people take besides Macrobid? *

Levaquin: 20 people, 40.82%
Zocor: 16 people, 32.65%
Flonase: 14 people, 28.57%
Allegra: 14 people, 28.57%
Lipitor: 8 people, 16.33%
Protonix: 7 people, 14.29%
Tysabri: 6 people, 12.24%
Sulfamethoxazole And Trimethoprim: 6 people, 12.24%
Furosemide: 6 people, 12.24%
Lasix: 6 people, 12.24%

What are other side effects people have besides Hepatic failure? *

Fatigue (feeling of tiredness): 24 people, 48.98%
Acute Kidney Failure: 23 people, 46.94%
Hepatic Encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure): 22 people, 44.90%
Weakness: 19 people, 38.78%
Ascites (accumulation of fluid in the abdominal cavity): 16 people, 32.65%
Back Pain: 15 people, 30.61%
Jaundice - Yellow Skin (a yellowish pigmentation of the skin): 15 people, 30.61%
Dehydration (dryness resulting from the removal of water): 14 people, 28.57%
Fever: 14 people, 28.57%
Muscle Aches (muscle pain): 14 people, 28.57%

What are the existing conditions these people have? *

Hyperlipidaemia (presence of excess lipids in the blood): 9 people, 18.37%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 12.24%
Depression: 5 people, 10.20%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 5 people, 10.20%
Insomnia (sleeplessness): 3 people, 6.12%
Muscle Spasms (muscle contraction): 2 people, 4.08%
Chronic Fatigue Syndrome (disorder that causes extreme fatigue): 2 people, 4.08%
High Blood Pressure: 2 people, 4.08%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 2 people, 4.08%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 2 people, 4.08%

* Approximation only. Some reports may have incomplete information.

Do you take Macrobid and have Hepatic failure?

- Check whether Hepatic failure is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Macrobid:

Macrobid (9,215 reports)

Hepatic failure treatments and more:

Hepatic failure (44,058 reports)

How severe was Hepatic failure and when was it recovered:

Hepatic failure in Macrobid

Expand to all the drugs that have ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline:

Hepatic failure and drugs with ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Macrobid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hepatic failure:

Hepatic failure (1,540 drugs)

Browse all the conditions that are associated with Hepatic failure:

Hepatic failure (1,892 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on nitrofurantoin; nitrofurantoin, macrocrystalline (the active ingredients of Macrobid) and Macrobid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.