Macrobid and Psychotic disorder - a phase IV clinical study of FDA data

Summary:

Psychotic disorder is reported as a side effect among people who take Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Crestor, and have Pain.

The phase IV clinical study analyzes which people have Psychotic disorder when taking Macrobid. It is created by eHealthMe based on reports of 8,335 people who have side effects when taking Macrobid from the FDA, and is updated regularly.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

What is Psychotic disorder?

Psychotic disorder is found to be associated with 1,230 drugs and 1,473 conditions by eHealthMe. Check the latest studies of Psychotic disorder.

On Aug, 12, 2026

8,335 people reported to have side effects when taking Macrobid.
Among them, 17 people (0.2%) have Psychotic disorder.

Could Macrobid cause Psychotic disorder?

Among these 17 people:

How long have people been on Macrobid when they have Psychotic disorder? *

What is the gender of people who have Psychotic disorder when taking Macrobid? *

female: 88.24 %
male: 11.76 %

What is the age of people who have Psychotic disorder when taking Macrobid? *

What are other drugs people take besides Macrobid? *

What are other side effects people have besides Psychotic disorder? *

Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 7 people, 41.18%
Stress And Anxiety: 7 people, 41.18%
Hallucination, Auditory (perceiving sounds without auditory stimulus): 7 people, 41.18%
Dyspnea (difficult or laboured breathing): 6 people, 35.29%
Pain In Extremity: 6 people, 35.29%
Weakness: 6 people, 35.29%
Nausea (feeling of having an urge to vomit): 5 people, 29.41%
Swallowing Difficulty: 5 people, 29.41%
Constipation: 5 people, 29.41%
Abdominal Pain Upper: 5 people, 29.41%

What are the existing conditions these people have? *

Pain: 4 people, 23.53%
Nausea (feeling of having an urge to vomit): 3 people, 17.65%
Nausea And Vomiting: 2 people, 11.76%
Stress And Anxiety: 1 person, 5.88%
Depression: 1 person, 5.88%
Bipolar Disorder (mood disorder): 1 person, 5.88%
Birth Control: 1 person, 5.88%
Cataract (clouding of the lens inside the eye): 1 person, 5.88%
Dehydration (dryness resulting from the removal of water): 1 person, 5.88%
Delusion (a false belief or opinion): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Macrobid and have Psychotic disorder?

- Check whether Psychotic disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Macrobid:

Macrobid (9,215 reports)

Psychotic disorder treatments and more:

Psychotic disorder (61,342 reports)

How severe was Psychotic disorder and when was it recovered:

Psychotic disorder in Macrobid

Expand to all the drugs that have ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline:

Psychotic disorder and drugs with ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Macrobid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Psychotic disorder:

Psychotic disorder (1,230 drugs)

Browse all the conditions that are associated with Psychotic disorder:

Psychotic disorder (1,473 conditions)

Related publications that referenced our studies

Kapoor S, "Influence of Vitamin D Consumption and Levels on the Development of Psychiatric Disorders", Lee, Y. J., & Park, K. (2018). Secondary Raynaud’s Phenomenon and Skin Necrosis of Toes in the Paraplegic Patient with Hypertension.?Drug safety-case reports,?5(1), 7., 2014 Aug .
Kapoor S, "Influence of Vitamin D Consumption and Levels on the Development of Psychiatric Disorders", Lee, Y. J., & Park, K. (2018). Secondary Raynaud’s Phenomenon and Skin Necrosis of Toes in the Paraplegic Patient with Hypertension.?Drug safety-case reports,?5(1), 7., 2014 Aug .

How the study uses the data?

The study uses data from the FDA. It is based on nitrofurantoin; nitrofurantoin, macrocrystalline (the active ingredients of Macrobid) and Macrobid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.