Macrobid and Splenomegaly - a phase IV clinical study of FDA data

Summary:

Splenomegaly is reported as a side effect among people who take Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Levaquin, and have Muscle spasms.

The phase IV clinical study analyzes which people have Splenomegaly when taking Macrobid. It is created by eHealthMe based on reports of 8,335 people who have side effects when taking Macrobid from the FDA, and is updated regularly.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

What is Splenomegaly?

Splenomegaly (enlargement of spleen) is found to be associated with 1,122 drugs and 1,477 conditions by eHealthMe. Check the latest studies of Splenomegaly.

On Jul, 05, 2026

8,335 people reported to have side effects when taking Macrobid.
Among them, 18 people (0.22%) have Splenomegaly.

Among these 18 people:

How long have people been on Macrobid when they have Splenomegaly? *

What is the gender of people who have Splenomegaly when taking Macrobid? *

female: 88.89 %
male: 11.11 %

What is the age of people who have Splenomegaly when taking Macrobid? *

What are other drugs people take besides Macrobid? *

What are other side effects people have besides Splenomegaly? *

Acute Kidney Failure: 10 people, 55.56%
Back Pain: 9 people, 50.00%
Muscle Aches (muscle pain): 9 people, 50.00%
Thrombocytopenia (decrease of platelets in blood): 8 people, 44.44%
Oedema Peripheral (superficial swelling): 7 people, 38.89%
Anaemia (lack of blood): 7 people, 38.89%
Pain: 7 people, 38.89%
Dizziness: 7 people, 38.89%
Weight Increased: 6 people, 33.33%
Osteomyelitis (infection of bone): 6 people, 33.33%

What are the existing conditions these people have? *

Pain: 5 people, 27.78%
Muscle Spasms (muscle contraction): 5 people, 27.78%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 16.67%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 16.67%
Primary Myelofibrosis (primary disorder of the bone marrow): 2 people, 11.11%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 11.11%
High Blood Pressure: 2 people, 11.11%
Skin Blushing/flushing (a sudden reddening of the face, neck): 1 person, 5.56%
Blood Pressure Abnormal: 1 person, 5.56%
Heart Rate Irregular: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Macrobid and have Splenomegaly?

- Check whether Splenomegaly is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Macrobid:

Macrobid (9,215 reports)

Splenomegaly treatments and more:

Splenomegaly (17,257 reports)

How severe was Splenomegaly and when was it recovered:

Splenomegaly in Macrobid

Expand to all the drugs that have ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline:

Splenomegaly and drugs with ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline (37 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Macrobid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Splenomegaly:

Splenomegaly (1,122 drugs)

Browse all the conditions that are associated with Splenomegaly:

Splenomegaly (1,477 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on nitrofurantoin; nitrofurantoin, macrocrystalline (the active ingredients of Macrobid) and Macrobid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.