Macrodantin and Ankle fracture - a phase IV clinical study of FDA data
Summary:
Ankle fracture is reported as a side effect among people who take Macrodantin (nitrofurantoin, macrocrystalline), especially for people who are female, 50-59 old, have been taking the drug for 10+ years also take Cymbalta, and have Multiple sclerosis.
The phase IV clinical study analyzes which people have Ankle fracture when taking Macrodantin. It is created by eHealthMe based on reports of 3,567 people who have side effects when taking Macrodantin from the FDA, and is updated regularly.
What is Macrodantin?
Macrodantin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 3,755 Macrodantin users. Check the latest studies of Macrodantin.
What is Ankle fracture?
Ankle fracture is found to be associated with 1,121 drugs and 1,049 conditions by eHealthMe. Check the latest studies of Ankle fracture.
3,567 people reported to have side effects when taking Macrodantin.
Among them, 11 people (0.31%) have Ankle fracture.

Among these 11 people:
How long have people been on Macrodantin when they have Ankle fracture? *
- < 1 month: 0.0 %
- 1 - 6 months: 0.0 %
- 6 - 12 months: 0.0 %
- 1 - 2 years: 50 %
- 2 - 5 years: 0.0 %
- 5 - 10 years: 0.0 %
- 10+ years: 50 %
What is the gender of people who have Ankle fracture when taking Macrodantin? *
- female: 81.82 %
- male: 18.18 %
What is the age of people who have Ankle fracture when taking Macrodantin? *
- 0-1: 0.0 %
- 2-9: 0.0 %
- 10-19: 0.0 %
- 20-29: 0.0 %
- 30-39: 0.0 %
- 40-49: 14.29 %
- 50-59: 71.43 %
- 60+: 14.29 %
What are other drugs people take besides Macrodantin? *
- Cymbalta: 5 people, 45.45%
- Paxil: 3 people, 27.27%
- Avonex: 3 people, 27.27%
- Ms Contin: 3 people, 27.27%
- Lamictal: 3 people, 27.27%
- Baclofen: 3 people, 27.27%
- Lexapro: 3 people, 27.27%
- Lyrica: 3 people, 27.27%
- Clonazepam: 2 people, 18.18%
- Omeprazole: 2 people, 18.18%
What are other side effects people have besides Ankle fracture? *
- Fall: 8 people, 72.73%
- Headache (pain in head): 4 people, 36.36%
- Joint Pain: 3 people, 27.27%
- Hypoaesthesia (reduced sense of touch or sensation): 3 people, 27.27%
- Fatigue (feeling of tiredness): 3 people, 27.27%
- High Blood Pressure: 3 people, 27.27%
- Osteoporosis (bones weak and more likely to break): 3 people, 27.27%
- Weight Increased: 2 people, 18.18%
- Gait Disturbance: 2 people, 18.18%
- Limb Injury: 2 people, 18.18%
What are the existing conditions these people have? *
- Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 36.36%
- Stress And Anxiety: 2 people, 18.18%
- Pain: 2 people, 18.18%
- Nausea (feeling of having an urge to vomit): 2 people, 18.18%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 18.18%
- Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 2 people, 18.18%
- Muscle Spasms (muscle contraction): 2 people, 18.18%
- Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 2 people, 18.18%
- Mood Swings (an extreme or rapid change in mood): 2 people, 18.18%
- Migraine (headache): 2 people, 18.18%
* Approximation only. Some reports may have incomplete information.
Do you take Macrodantin and have Ankle fracture?
- Check whether Ankle fracture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, long term effects of, and alternative drugs to Macrodantin:
- Macrodantin (3,755 reports)
Ankle fracture treatments and more:
- Ankle fracture (20,557 reports)
How severe was Ankle fracture and when was it recovered:
Expand to all the drugs that have ingredients of nitrofurantoin, macrocrystalline:
Sub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Macrodantin:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all the drugs that are associated with Ankle fracture:
- Ankle fracture (1,121 drugs)
Browse all the conditions that are associated with Ankle fracture:
- Ankle fracture (1,049 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on nitrofurantoin, macrocrystalline (the active ingredients of Macrodantin) and Macrodantin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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