Macrodantin and Enlarged heart - a phase IV clinical study of FDA data

Summary:

Enlarged heart is reported as a side effect among people who take Macrodantin (nitrofurantoin, macrocrystalline), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Levaquin, and have Depression.

The phase IV clinical study analyzes which people have Enlarged heart when taking Macrodantin. It is created by eHealthMe based on reports of 3,567 people who have side effects when taking Macrodantin from the FDA, and is updated regularly.

What is Macrodantin?

Macrodantin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 3,755 Macrodantin users. Check the latest studies of Macrodantin.

What is Enlarged heart?

Enlarged heart is found to be associated with 1,456 drugs and 1,663 conditions by eHealthMe. Check the latest studies of Enlarged heart.

On Jul, 12, 2026

3,567 people reported to have side effects when taking Macrodantin.
Among them, 37 people (1.04%) have Enlarged heart.

Among these 37 people:

How long have people been on Macrodantin when they have Enlarged heart? *

What is the gender of people who have Enlarged heart when taking Macrodantin? *

female: 69.7 %
male: 30.3 %

What is the age of people who have Enlarged heart when taking Macrodantin? *

What are other drugs people take besides Macrodantin? *

What are other side effects people have besides Enlarged heart? *

Pain: 17 people, 45.95%
Stress And Anxiety: 17 people, 45.95%
Tricuspid Valve Incompetence (inefficient heart valve): 15 people, 40.54%
Mitral Valve Incompetence (inefficient heart valve): 14 people, 37.84%
Cardiac Failure Congestive: 13 people, 35.14%
Cardiac Murmur (an heart sound in valve abnormality): 13 people, 35.14%
Swelling: 13 people, 35.14%
Aortic Valve Incompetence: 11 people, 29.73%
Drug Exposure During Pregnancy: 10 people, 27.03%
Fatigue (feeling of tiredness): 10 people, 27.03%

What are the existing conditions these people have? *

Depression: 9 people, 24.32%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 16.22%
Metastases To Bone (cancer spreads to bone): 4 people, 10.81%
Stress And Anxiety: 4 people, 10.81%
Cardiac Failure Congestive: 2 people, 5.41%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 5.41%
Kidney Infection (Pyelonephritis): 2 people, 5.41%
Blood Iron Increased: 2 people, 5.41%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 1 person, 2.70%
Urinary Tract Disorder: 1 person, 2.70%

* Approximation only. Some reports may have incomplete information.

Do you take Macrodantin and have Enlarged heart?

- Check whether Enlarged heart is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Macrodantin:

Macrodantin (3,755 reports)

Enlarged heart treatments and more:

Enlarged heart (20,022 reports)

How severe was Enlarged heart and when was it recovered:

Enlarged heart in Macrodantin

Expand to all the drugs that have ingredients of nitrofurantoin, macrocrystalline:

Enlarged heart and drugs with ingredients of nitrofurantoin, macrocrystalline (59 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Macrodantin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Enlarged heart:

Enlarged heart (1,456 drugs)

Browse all the conditions that are associated with Enlarged heart:

Enlarged heart (1,663 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on nitrofurantoin, macrocrystalline (the active ingredients of Macrodantin) and Macrodantin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.