Macrodantin and Injection site reaction - a phase IV clinical study of FDA data

Summary:

Injection site reaction is reported as a side effect among people who take Macrodantin (nitrofurantoin, macrocrystalline), especially for people who are female, 50-59 old, also take Singulair, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Injection site reaction when taking Macrodantin. It is created by eHealthMe based on reports of 3,567 people who have side effects when taking Macrodantin from the FDA, and is updated regularly.

What is Macrodantin?

Macrodantin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 3,755 Macrodantin users. Check the latest studies of Macrodantin.

What is Injection site reaction?

Injection site reaction is found to be associated with 1,128 drugs and 1,074 conditions by eHealthMe. Check the latest studies of Injection site reaction.

On Jul, 12, 2026

3,567 people reported to have side effects when taking Macrodantin.
Among them, 12 people (0.34%) have Injection site reaction.

Could Macrodantin cause Injection site reaction?

Among these 12 people:

What is the gender of people who have Injection site reaction when taking Macrodantin? *

female: 100 %
male: 0.0 %

What is the age of people who have Injection site reaction when taking Macrodantin? *

What are other drugs people take besides Macrodantin? *

What are other side effects people have besides Injection site reaction? *

Injection Site Pruritus (severe itching at injection site): 6 people, 50.00%
Injection Site Pain: 5 people, 41.67%
Injection Site Erythema (redness at injection site): 3 people, 25.00%
Drug Ineffective: 3 people, 25.00%
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 2 people, 16.67%
Injection Site Warmth: 2 people, 16.67%
Itching: 2 people, 16.67%
Joint Pain: 2 people, 16.67%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 2 people, 16.67%
Nausea (feeling of having an urge to vomit): 2 people, 16.67%

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 16.67%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 16.67%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 16.67%
Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 2 people, 16.67%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 16.67%
Thyroid Diseases: 1 person, 8.33%
Arthropathy: 1 person, 8.33%
Asthma: 1 person, 8.33%
Breast Cancer Female: 1 person, 8.33%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Macrodantin and have Injection site reaction?

- Check whether Injection site reaction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Macrodantin:

Macrodantin (3,755 reports)

Injection site reaction treatments and more:

Injection site reaction (66,073 reports)

How severe was Injection site reaction and when was it recovered:

Injection site reaction in Macrodantin

Expand to all the drugs that have ingredients of nitrofurantoin, macrocrystalline:

Injection site reaction and drugs with ingredients of nitrofurantoin, macrocrystalline

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Macrodantin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Injection site reaction:

Injection site reaction (1,128 drugs)

Browse all the conditions that are associated with Injection site reaction:

Injection site reaction (1,074 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on nitrofurantoin, macrocrystalline (the active ingredients of Macrodantin) and Macrodantin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.