Macrodantin and Multiple sclerosis - a phase IV clinical study of FDA data

Summary:

Multiple sclerosis is reported as a side effect among people who take Macrodantin (nitrofurantoin, macrocrystalline), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Avonex, and have Relapsing-remitting multiple sclerosis.

The phase IV clinical study analyzes which people have Multiple sclerosis when taking Macrodantin. It is created by eHealthMe based on reports of 3,567 people who have side effects when taking Macrodantin from the FDA, and is updated regularly.

What is Macrodantin?

Macrodantin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 3,755 Macrodantin users. Check the latest studies of Macrodantin.

What is Multiple sclerosis?

Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath) is found to be associated with 1,084 drugs and 1,366 conditions by eHealthMe. Check the latest studies of Multiple sclerosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 11, 2026

3,567 people reported to have side effects when taking Macrodantin.
Among them, 51 people (1.43%) have Multiple sclerosis.

Could Macrodantin cause Multiple sclerosis?

Among these 51 people:

How long have people been on Macrodantin when they have Multiple sclerosis? *

What is the gender of people who have Multiple sclerosis when taking Macrodantin? *

female: 84.31 %
male: 15.69 %

What is the age of people who have Multiple sclerosis when taking Macrodantin? *

What are other drugs people take besides Macrodantin? *

What are other side effects people have besides Multiple sclerosis? *

Weakness: 10 people, 19.61%
Fatigue (feeling of tiredness): 10 people, 19.61%
Headache (pain in head): 7 people, 13.73%
Memory Loss: 7 people, 13.73%
Malaise (a feeling of general discomfort or uneasiness): 7 people, 13.73%
Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 13.73%
Fall: 7 people, 13.73%
Gait Disturbance: 6 people, 11.76%
Depression: 6 people, 11.76%
Fever: 6 people, 11.76%

What are the existing conditions these people have? *

Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 7 people, 13.73%
Insomnia (sleeplessness): 5 people, 9.80%
Gait Disturbance: 4 people, 7.84%
High Blood Pressure: 4 people, 7.84%
Fever: 4 people, 7.84%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 5.88%
High Blood Cholesterol: 3 people, 5.88%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 5.88%
Diarrhea: 3 people, 5.88%
Nausea And Vomiting: 3 people, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Macrodantin and have Multiple sclerosis?

- Check whether Multiple sclerosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Macrodantin:

Macrodantin (3,755 reports)

Multiple sclerosis treatments and more:

Multiple sclerosis (799,637 reports)

How severe was Multiple sclerosis and when was it recovered:

Multiple sclerosis in Macrodantin

Expand to all the drugs that have ingredients of nitrofurantoin, macrocrystalline:

Multiple sclerosis and drugs with ingredients of nitrofurantoin, macrocrystalline (98 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Macrodantin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Multiple sclerosis:

Multiple sclerosis (1,084 drugs)

Browse all the conditions that are associated with Multiple sclerosis:

Multiple sclerosis (1,366 conditions)

Related publications that referenced our studies

Christopher KL, Elner VM, Demirci H, "Conjunctival Lymphoma in a Patient on Fingolimod for Relapsing-Remitting Multiple Sclerosis", Ophthalmic Plastic & Reconstructive Surgery, 2017 May .
Christopher, K. L., Elner, V. M., & Demirci, H. , "Conjunctival lymphoma in a patient on fingolimod for relapsing-remitting multiple sclerosis", Ophthalmic plastic and reconstructive surgery , 2014 Jan .
Christopher KL, Elner VM, Demirci H, "Conjunctival Lymphoma in a Patient on Fingolimod for Relapsing-Remitting Multiple Sclerosis", Ophthalmic Plastic & Reconstructive Surgery, 2017 May .
Christopher, K. L., Elner, V. M., & Demirci, H. , "Conjunctival lymphoma in a patient on fingolimod for relapsing-remitting multiple sclerosis", Ophthalmic plastic and reconstructive surgery , 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on nitrofurantoin, macrocrystalline (the active ingredients of Macrodantin) and Macrodantin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.