Macrodantin and Seizures - a phase IV clinical study of FDA data

Summary:

Seizures is reported as a side effect among people who take Macrodantin (nitrofurantoin, macrocrystalline), especially for people who are female, 2-9 old, have been taking the drug for < 1 month also take Epinephrine, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Seizures when taking Macrodantin. It is created by eHealthMe based on reports of 3,567 people who have side effects when taking Macrodantin from the FDA, and is updated regularly.

What is Macrodantin?

Macrodantin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 3,755 Macrodantin users. Check the latest studies of Macrodantin.

What is Seizures?

Seizures (abnormal excessive or synchronous neuronal activity in the brain) is found to be associated with 1,994 drugs and 2,277 conditions by eHealthMe. Check the latest studies of Seizures.

On Jul, 17, 2026

3,567 people reported to have side effects when taking Macrodantin.
Among them, 38 people (1.07%) have Seizures.

Among these 38 people:

How long have people been on Macrodantin when they have Seizures? *

What is the gender of people who have Seizures when taking Macrodantin? *

female: 51.35 %
male: 48.65 %

What is the age of people who have Seizures when taking Macrodantin? *

What are other drugs people take besides Macrodantin? *

What are other side effects people have besides Seizures? *

Fever: 11 people, 28.95%
Hypotension (abnormally low blood pressure): 7 people, 18.42%
Stress And Anxiety: 6 people, 15.79%
Otitis (ear infection): 5 people, 13.16%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 13.16%
Gait Disturbance: 5 people, 13.16%
Blood Sodium Decreased: 5 people, 13.16%
Dyskinesia (abnormality or impairment of voluntary movement): 5 people, 13.16%
Dyspnea (difficult or laboured breathing): 5 people, 13.16%
White Blood Cell Count Increased: 4 people, 10.53%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 10 people, 26.32%
Constipation: 6 people, 15.79%
Lennox-Gastaut Syndrome (epilepsy characterized by frequent seizures and different seizure types): 5 people, 13.16%
Gait Disturbance: 3 people, 7.89%
Immunodeficiency: 3 people, 7.89%
Laxative Supportive Care: 3 people, 7.89%
Drowsiness: 3 people, 7.89%
Muscle Spasms (muscle contraction): 3 people, 7.89%
Pain: 2 people, 5.26%
Neurogenic Bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion): 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Macrodantin and have Seizures?

- Check whether Seizures is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Macrodantin:

Macrodantin (3,755 reports)

Seizures treatments and more:

Seizures (150,179 reports)

How severe was Seizures and when was it recovered:

Seizures in Macrodantin

Expand to all the drugs that have ingredients of nitrofurantoin, macrocrystalline:

Seizures and drugs with ingredients of nitrofurantoin, macrocrystalline (22 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Macrodantin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Seizures:

Seizures (1,994 drugs)

Browse all the conditions that are associated with Seizures:

Seizures (2,277 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on nitrofurantoin, macrocrystalline (the active ingredients of Macrodantin) and Macrodantin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.