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Magnesium citrate and Hypothyroidism - a phase IV clinical study of FDA data

Summary:

Hypothyroidism is reported as a side effect among people who take Magnesium citrate (magnesium), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Amlodipine, and have Hepatocellular carcinoma.

The phase IV clinical study analyzes which people have Hypothyroidism when taking Magnesium citrate. It is created by eHealthMe based on reports of 5,439 people who have side effects when taking Magnesium citrate from the FDA, and is updated regularly.

What is Magnesium citrate?

Magnesium citrate has active ingredients of magnesium. It is often used in constipation. eHealthMe is studying from 5,790 Magnesium citrate users. Check the latest studies of Magnesium citrate.

What is Hypothyroidism?

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development) is found to be associated with 1,616 drugs and 2,600 conditions by eHealthMe. Check the latest studies of Hypothyroidism.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

5,439 people reported to have side effects when taking Magnesium citrate.
Among them, 40 people (0.74%) have Hypothyroidism.

Could Magnesium citrate cause Hypothyroidism?

Among these 40 people:

How long have people been on Magnesium citrate when they have Hypothyroidism? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 100 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Hypothyroidism when taking Magnesium citrate? *

  • female: 61.11 %
  • male: 38.89 %

What is the age of people who have Hypothyroidism when taking Magnesium citrate? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 11.54 %
  • 40-49: 3.85 %
  • 50-59: 7.69 %
  • 60+: 76.92 %

What are other drugs people take besides Magnesium citrate? *

  1. Amlodipine: 11 people, 27.50%
  2. Magnesium Aspartate: 10 people, 25.00%
  3. Lansoprazole: 10 people, 25.00%
  4. Tramadol: 9 people, 22.50%
  5. Xyrem: 8 people, 20.00%
  6. Synthroid: 7 people, 17.50%
  7. Melatonin: 5 people, 12.50%
  8. Vitamin D3: 5 people, 12.50%
  9. Doxycycline: 5 people, 12.50%
  10. Singulair: 5 people, 12.50%

What are other side effects people have besides Hypothyroidism? *

  1. Weight Decreased: 17 people, 42.50%
  2. Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 14 people, 35.00%
  3. Fatigue (feeling of tiredness): 11 people, 27.50%
  4. Blood Magnesium Decreased: 11 people, 27.50%
  5. Weakness: 10 people, 25.00%
  6. High Blood Pressure: 9 people, 22.50%
  7. Dizziness: 7 people, 17.50%
  8. Gait Disturbance: 7 people, 17.50%
  9. Nausea (feeling of having an urge to vomit): 6 people, 15.00%
  10. Malaise (a feeling of general discomfort or uneasiness): 6 people, 15.00%

What are the existing conditions these people have? *

  1. Hepatocellular Carcinoma (liver cancer): 14 people, 35.00%
  2. Pain In Jaw: 10 people, 25.00%
  3. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 20.00%
  4. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 20.00%
  5. Arthritis Infective (purulent invasion of a joint by an infectious agent which produces arthritis): 4 people, 10.00%
  6. Itching: 4 people, 10.00%
  7. Depression: 3 people, 7.50%
  8. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 2 people, 5.00%
  9. Renal Cell Carcinoma (a kidney cancer): 2 people, 5.00%
  10. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Magnesium citrate and have Hypothyroidism?

- Check whether Hypothyroidism is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Magnesium citrate:

Hypothyroidism treatments and more:

How severe was Hypothyroidism and when was it recovered:

Expand to all the drugs that have ingredients of magnesium:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Magnesium citrate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypothyroidism:

Browse all the conditions that are associated with Hypothyroidism:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on magnesium (the active ingredients of Magnesium citrate) and Magnesium citrate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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