Malarone and Chills - a phase IV clinical study of FDA data

Summary:

Chills is reported as a side effect among people who take Malarone (atovaquone; proguanil hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Imodium, and have Plasmodium falciparum infection.

The phase IV clinical study analyzes which people have Chills when taking Malarone. It is created by eHealthMe based on reports of 2,660 people who have side effects when taking Malarone from the FDA, and is updated regularly.

What is Malarone?

Malarone has active ingredients of atovaquone; proguanil hydrochloride. It is often used in malaria. eHealthMe is studying from 3,098 Malarone users. Check the latest studies of Malarone.

What is Chills?

Chills (felling of cold) is found to be associated with 2,549 drugs and 3,475 conditions by eHealthMe. Check the latest studies of Chills.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 04, 2026

2,660 people reported to have side effects when taking Malarone.
Among them, 45 people (1.69%) have Chills.

Among these 45 people:

How long have people been on Malarone when they have Chills? *

What is the gender of people who have Chills when taking Malarone? *

female: 55.56 %
male: 44.44 %

What is the age of people who have Chills when taking Malarone? *

What are other drugs people take besides Malarone? *

What are other side effects people have besides Chills? *

Fever: 28 people, 62.22%
Fatigue (feeling of tiredness): 14 people, 31.11%
Headache (pain in head): 12 people, 26.67%
Malaise (a feeling of general discomfort or uneasiness): 10 people, 22.22%
Diarrhea: 10 people, 22.22%
Drug Ineffective: 9 people, 20.00%
Nausea (feeling of having an urge to vomit): 9 people, 20.00%
Cough: 9 people, 20.00%
Hyperhidrosis (abnormally increased sweating): 8 people, 17.78%
Weakness: 8 people, 17.78%

What are the existing conditions these people have? *

Plasmodium Falciparum Infection (malaria caused by the protozoan parasite plasmodium falciparum): 2 people, 4.44%
Urination - Excessive At Night: 1 person, 2.22%
Seasonal Allergy (allergic condition due to certain season): 1 person, 2.22%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 1 person, 2.22%
Nervous System Disorder (a general class of medical conditions affecting the nervous system): 1 person, 2.22%
Nausea And Vomiting: 1 person, 2.22%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 1 person, 2.22%
Lyme Disease (a bacterial infection that is spread to humans by infected ticks): 1 person, 2.22%
Irritable Bowel Syndrome: 1 person, 2.22%
Headache (pain in head): 1 person, 2.22%

* Approximation only. Some reports may have incomplete information.

Do you take Malarone and have Chills?

- Check whether Chills is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Malarone:

Malarone (3,098 reports)

Chills treatments and more:

Chills (145,628 reports)

How severe was Chills and when was it recovered:

Chills in Malarone

Expand to all the drugs that have ingredients of atovaquone; proguanil hydrochloride:

Chills and drugs with ingredients of atovaquone; proguanil hydrochloride (48 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Malarone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Chills:

Chills (2,549 drugs)

Browse all the conditions that are associated with Chills:

Chills (3,475 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on atovaquone; proguanil hydrochloride (the active ingredients of Malarone) and Malarone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.