Malarone and Lyme disease - a phase IV clinical study of FDA data

Summary:

Lyme disease is reported as a side effect among people who take Malarone (atovaquone; proguanil hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lexapro, and have Cataplexy.

The phase IV clinical study analyzes which people have Lyme disease when taking Malarone. It is created by eHealthMe based on reports of 2,660 people who have side effects when taking Malarone from the FDA, and is updated regularly.

What is Malarone?

Malarone has active ingredients of atovaquone; proguanil hydrochloride. It is often used in malaria. eHealthMe is studying from 3,098 Malarone users. Check the latest studies of Malarone.

What is Lyme disease?

Lyme disease (a bacterial infection that is spread to humans by infected ticks) is found to be associated with 429 drugs and 621 conditions by eHealthMe. Check the latest studies of Lyme disease.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 14, 2026

2,660 people reported to have side effects when taking Malarone.
Among them, 12 people (0.45%) have Lyme disease.

Among these 12 people:

How long have people been on Malarone when they have Lyme disease? *

What is the gender of people who have Lyme disease when taking Malarone? *

female: 83.33 %
male: 16.67 %

What is the age of people who have Lyme disease when taking Malarone? *

What are other drugs people take besides Malarone? *

What are other side effects people have besides Lyme disease? *

Fatigue (feeling of tiredness): 6 people, 50.00%
Tinnitus (a ringing in the ears): 6 people, 50.00%
Demyelination (loss of the myelin covering of some nerve fibres resulting in their impaired function): 4 people, 33.33%
Pain: 4 people, 33.33%
Stress And Anxiety: 3 people, 25.00%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 3 people, 25.00%
Concussion (short loss of normal brain function in response to a head injury): 3 people, 25.00%
Post-Traumatic Stress Disorder: 3 people, 25.00%
Fall: 3 people, 25.00%
Neuropathy Peripheral (surface nerve damage): 3 people, 25.00%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 50.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 50.00%
Drowsiness: 2 people, 16.67%
Rash Morbilliform (a rash that looks like measles): 1 person, 8.33%
Parasite Blood Test Positive: 1 person, 8.33%
Osteoporosis (bones weak and more likely to break): 1 person, 8.33%
Insomnia (sleeplessness): 1 person, 8.33%
Bone Density Decreased: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Malarone and have Lyme disease?

- Check whether Lyme disease is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Malarone:

Malarone (3,098 reports)

Lyme disease treatments and more:

Lyme disease (6,358 reports)

How severe was Lyme disease and when was it recovered:

Lyme disease in Malarone

Expand to all the drugs that have ingredients of atovaquone; proguanil hydrochloride:

Lyme disease and drugs with ingredients of atovaquone; proguanil hydrochloride (7 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Malarone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Lyme disease:

Lyme disease (429 drugs)

Browse all the conditions that are associated with Lyme disease:

Lyme disease (621 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on atovaquone; proguanil hydrochloride (the active ingredients of Malarone) and Malarone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.