Meclizine and Progressive multifocal leukoencephalopathy - a phase IV clinical study of FDA data

Summary:

Progressive multifocal leukoencephalopathy is reported as a side effect among people who take Meclizine (meclizine hydrochloride), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Tysabri, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Progressive multifocal leukoencephalopathy when taking Meclizine. It is created by eHealthMe based on reports of 22,264 people who have side effects when taking Meclizine from the FDA, and is updated regularly.

What is Meclizine?

Meclizine has active ingredients of meclizine hydrochloride. It is often used in dizziness. eHealthMe is studying from 23,117 Meclizine users. Check the latest studies of Meclizine.

What is Progressive multifocal leukoencephalopathy?

Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells) is found to be associated with 591 drugs and 921 conditions by eHealthMe. Check the latest studies of Progressive multifocal leukoencephalopathy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 28, 2026

22,264 people reported to have side effects when taking Meclizine.
Among them, 21 people (0.09%) have Progressive multifocal leukoencephalopathy.

Could Meclizine cause Progressive multifocal leukoencephalopathy?

Among these 21 people:

How long have people been on Meclizine when they have Progressive multifocal leukoencephalopathy? *

What is the gender of people who have Progressive multifocal leukoencephalopathy when taking Meclizine? *

female: 76.19 %
male: 23.81 %

What is the age of people who have Progressive multifocal leukoencephalopathy when taking Meclizine? *

What are other drugs people take besides Meclizine? *

What are other side effects people have besides Progressive multifocal leukoencephalopathy? *

Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 14 people, 66.67%
Speech Impairment (Adult) (inability to speak (adult)): 12 people, 57.14%
Movement - Uncoordinated: 11 people, 52.38%
Mental Status Changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 11 people, 52.38%
Back Pain: 9 people, 42.86%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 8 people, 38.10%
Immune Reconstitution Syndrome (immune recovery syndrome): 8 people, 38.10%
Respiratory Depression (respiration has a rate below 12 breaths): 6 people, 28.57%
Pneumonia: 5 people, 23.81%
Dementia (madness): 4 people, 19.05%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 19 people, 90.48%
Muscle Spasms (muscle contraction): 11 people, 52.38%
Headache (pain in head): 9 people, 42.86%
Diabetes: 9 people, 42.86%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 5 people, 23.81%
Pain: 2 people, 9.52%
Insomnia (sleeplessness): 2 people, 9.52%
Indigestion: 2 people, 9.52%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 9.52%
High Blood Cholesterol: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

Do you take Meclizine and have Progressive multifocal leukoencephalopathy?

- Check whether Progressive multifocal leukoencephalopathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Meclizine:

Meclizine (23,117 reports)

Progressive multifocal leukoencephalopathy treatments and more:

Progressive multifocal leukoencephalopathy (13,731 reports)

How severe was Progressive multifocal leukoencephalopathy and when was it recovered:

Progressive multifocal leukoencephalopathy in Meclizine

Expand to all the drugs that have ingredients of meclizine hydrochloride:

Progressive multifocal leukoencephalopathy and drugs with ingredients of meclizine hydrochloride

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Meclizine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Progressive multifocal leukoencephalopathy:

Progressive multifocal leukoencephalopathy (591 drugs)

Browse all the conditions that are associated with Progressive multifocal leukoencephalopathy:

Progressive multifocal leukoencephalopathy (921 conditions)

Related publications that referenced our studies

Hassan JK, "POTENTIAL POSITIVE EFFECT OF ORAL PYRIDOXINE ALONE AND IN COMBINATION WITH MECLIZINE ON CIGARETTES SMOKING DURING TENDAYS’TRIAL", IJPSR, 2015 Jan .
Hassan JK, "POTENTIAL POSITIVE EFFECT OF ORAL PYRIDOXINE ALONE AND IN COMBINATION WITH MECLIZINE ON CIGARETTES SMOKING DURING TENDAYS’TRIAL", IJPSR, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on meclizine hydrochloride (the active ingredients of Meclizine) and Meclizine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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