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Megace and Cognitive disorder - a phase IV clinical study of FDA data

Summary:

Cognitive disorder is reported as a side effect among people who take Megace (megestrol acetate), especially for people who are female, 60+ old, also take Zofran, and have Nausea.

The phase IV clinical study analyzes which people have Cognitive disorder when taking Megace. It is created by eHealthMe based on reports of 9,969 people who have side effects when taking Megace from the FDA, and is updated regularly.

What is Megace?

Megace has active ingredients of megestrol acetate. It is often used in weight loss. eHealthMe is studying from 10,095 Megace users. Check the latest studies of Megace.

What is Cognitive disorder?

Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving) is found to be associated with 1,649 drugs and 1,729 conditions by eHealthMe. Check the latest studies of Cognitive disorder.

On Aug, 13, 2026

9,969 people reported to have side effects when taking Megace.
Among them, 48 people (0.48%) have Cognitive disorder.

Could Megace cause Cognitive disorder?

Among these 48 people:

What is the gender of people who have Cognitive disorder when taking Megace? *

  • female: 64.58 %
  • male: 35.42 %

What is the age of people who have Cognitive disorder when taking Megace? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 2.5 %
  • 50-59: 7.5 %
  • 60+: 90.0 %

What are other drugs people take besides Megace? *

  1. Zofran: 19 people, 39.58%
  2. Aspirin: 18 people, 37.50%
  3. Sunitinib Malate: 16 people, 33.33%
  4. Colace: 16 people, 33.33%
  5. Simvastatin: 16 people, 33.33%
  6. Actonel: 15 people, 31.25%
  7. Lortab: 15 people, 31.25%
  8. Ranitidine: 14 people, 29.17%
  9. Carvedilol: 9 people, 18.75%
  10. Tessalon: 9 people, 18.75%

What are other side effects people have besides Cognitive disorder? *

  1. Fatigue (feeling of tiredness): 27 people, 56.25%
  2. Nausea And Vomiting: 24 people, 50.00%
  3. Abdominal Pain: 22 people, 45.83%
  4. Headache (pain in head): 17 people, 35.42%
  5. Malaise (a feeling of general discomfort or uneasiness): 16 people, 33.33%
  6. Nausea (feeling of having an urge to vomit): 13 people, 27.08%
  7. Confusional State: 12 people, 25.00%
  8. Diarrhea: 9 people, 18.75%
  9. Memory Loss: 9 people, 18.75%
  10. Weakness: 8 people, 16.67%

What are the existing conditions these people have? *

  1. Nausea (feeling of having an urge to vomit): 13 people, 27.08%
  2. Iron Deficiency: 11 people, 22.92%
  3. Appetite Disorder (abnormal eating habits): 8 people, 16.67%
  4. Renal Cell Carcinoma (a kidney cancer): 8 people, 16.67%
  5. Pain In Extremity: 7 people, 14.58%
  6. Constipation: 7 people, 14.58%
  7. High Blood Cholesterol: 7 people, 14.58%
  8. Gastric Ulcer (stomach ulcer): 7 people, 14.58%
  9. Lung Cancer - Non-Small Cell (lung cancer): 6 people, 12.50%
  10. Diabetes: 6 people, 12.50%

* Approximation only. Some reports may have incomplete information.

Do you take Megace and have Cognitive disorder?

- Check whether Cognitive disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Megace:

Cognitive disorder treatments and more:

How severe was Cognitive disorder and when was it recovered:

Expand to all the drugs that have ingredients of megestrol acetate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Megace:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cognitive disorder:

Browse all the conditions that are associated with Cognitive disorder:

How the study uses the data?

The study uses data from the FDA. It is based on megestrol acetate (the active ingredients of Megace) and Megace (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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