Melatonin and Affective disorder - a phase IV clinical study of FDA data

Summary:

Affective disorder is reported as a side effect among people who take Melatonin (melatonin), especially for people who are female, 10-19 old, also take Xyrem, and have Narcolepsy.

The phase IV clinical study analyzes which people have Affective disorder when taking Melatonin. It is created by eHealthMe based on reports of 53,570 people who have side effects when taking Melatonin from the FDA, and is updated regularly.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

What is Affective disorder?

Affective disorder (mental disorder) is found to be associated with 716 drugs and 782 conditions by eHealthMe. Check the latest studies of Affective disorder.

On Jul, 10, 2026

53,570 people reported to have side effects when taking Melatonin.
Among them, 62 people (0.12%) have Affective disorder.

Could Melatonin cause Affective disorder?

Among these 62 people:

What is the gender of people who have Affective disorder when taking Melatonin? *

female: 61.82 %
male: 38.18 %

What is the age of people who have Affective disorder when taking Melatonin? *

What are other drugs people take besides Melatonin? *

What are other side effects people have besides Affective disorder? *

Depression: 18 people, 29.03%
Stress And Anxiety: 17 people, 27.42%
Fatigue (feeling of tiredness): 14 people, 22.58%
Drug Ineffective: 9 people, 14.52%
Suicidal Ideation: 8 people, 12.90%
Memory Loss: 7 people, 11.29%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 7 people, 11.29%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 6 people, 9.68%
Abnormal Behavior: 6 people, 9.68%
Balance Disorder: 5 people, 8.06%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 19.35%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 16.13%
Stress And Anxiety: 6 people, 9.68%
Parkinson's Disease: 6 people, 9.68%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 6.45%
Bipolar Disorder (mood disorder): 4 people, 6.45%
High Blood Pressure: 3 people, 4.84%
Drowsiness: 3 people, 4.84%
Constipation: 3 people, 4.84%
Depression: 3 people, 4.84%

* Approximation only. Some reports may have incomplete information.

Do you take Melatonin and have Affective disorder?

- Check whether Affective disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Melatonin:

Melatonin (56,212 reports)

Browse all side effects of Melatonin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Affective disorder:

Affective disorder (716 drugs)

Browse all the conditions that are associated with Affective disorder:

Affective disorder (782 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on melatonin (the active ingredients of Melatonin) and Melatonin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.