Melatonin and Hiccups - a phase IV clinical study of FDA data

Summary:

Hiccups is reported as a side effect among people who take Melatonin (melatonin), especially for people who are female, 60+ old, also take Magnesium, and have Seizures.

The phase IV clinical study analyzes which people have Hiccups when taking Melatonin. It is created by eHealthMe based on reports of 53,570 people who have side effects when taking Melatonin from the FDA, and is updated regularly.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

What is Hiccups?

Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough) is found to be associated with 697 drugs and 1,177 conditions by eHealthMe. Check the latest studies of Hiccups.



On Jul, 18, 2026

53,570 people reported to have side effects when taking Melatonin.
Among them, 33 people (0.06%) have Hiccups.

Could Melatonin cause Hiccups?

Among these 33 people:

What is the gender of people who have Hiccups when taking Melatonin? *

  • female: 69.7 %
  • male: 30.3 %

What is the age of people who have Hiccups when taking Melatonin? *

  • 0-1: 0.0 %
  • 2-9: 3.45 %
  • 10-19: 10.34 %
  • 20-29: 0.0 %
  • 30-39: 13.79 %
  • 40-49: 6.9 %
  • 50-59: 6.9 %
  • 60+: 58.62 %

What are other drugs people take besides Melatonin? *

  1. Magnesium: 6 people, 18.18%
  2. Dilantin: 5 people, 15.15%
  3. Vitamin C: 5 people, 15.15%
  4. Aubagio: 4 people, 12.12%
  5. Biotin: 4 people, 12.12%
  6. Zofran: 4 people, 12.12%
  7. Xarelto: 4 people, 12.12%
  8. Epipen: 4 people, 12.12%
  9. Pentasa: 4 people, 12.12%
  10. Neurontin: 4 people, 12.12%

What are other side effects people have besides Hiccups? *

  1. Nausea (feeling of having an urge to vomit): 17 people, 51.52%
  2. Nausea And Vomiting: 15 people, 45.45%
  3. Diarrhea: 13 people, 39.39%
  4. Malaise (a feeling of general discomfort or uneasiness): 12 people, 36.36%
  5. Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 10 people, 30.30%
  6. Fatigue (feeling of tiredness): 10 people, 30.30%
  7. Weakness: 10 people, 30.30%
  8. Feeling Abnormal: 10 people, 30.30%
  9. Pain In Extremity: 9 people, 27.27%
  10. Headache (pain in head): 9 people, 27.27%

What are the existing conditions these people have? *

  1. Seizures (abnormal excessive or synchronous neuronal activity in the brain): 6 people, 18.18%
  2. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 4 people, 12.12%
  3. High Blood Pressure: 4 people, 12.12%
  4. Cardiac Disorder: 4 people, 12.12%
  5. Partial Seizures (seizures which affect only a part of the brain at onset): 4 people, 12.12%
  6. Oesophageal Disorder (disease of oesophagus): 4 people, 12.12%
  7. Functional Gastrointestinal Disorder (functional problem in separate organs of gastrointestinal system): 4 people, 12.12%
  8. Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 4 people, 12.12%
  9. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 12.12%
  10. Pain: 3 people, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Melatonin and have Hiccups?

- Check whether Hiccups is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, long term effects of, and alternative drugs to Melatonin:

Hiccups treatments and more:

How severe was Hiccups and when was it recovered:

Expand to all the drugs that have ingredients of melatonin:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Melatonin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hiccups:

Browse all the conditions that are associated with Hiccups:


How the study uses the data?

The study uses data from the FDA. It is based on melatonin (the active ingredients of Melatonin) and Melatonin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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