Melatonin and Joint instability - a phase IV clinical study of FDA data

Summary:

Joint instability is reported as a side effect among people who take Melatonin (melatonin), especially for people who are female, 60+ old, also take Vitamin B12, and have High blood pressure.

The phase IV clinical study analyzes which people have Joint instability when taking Melatonin. It is created by eHealthMe based on reports of 53,570 people who have side effects when taking Melatonin from the FDA, and is updated regularly.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,208 Melatonin users. Check the latest studies of Melatonin.

What is Joint instability?

Joint instability (a condition in which the joints aren't sufficiently supported) is found to be associated with 236 drugs and 370 conditions by eHealthMe. Check the latest studies of Joint instability.

On Feb, 09, 2026

53,570 people reported to have side effects when taking Melatonin.
Among them, 14 people (0.03%) have Joint instability.

Could Melatonin cause Joint instability?

Among these 14 people:

What is the gender of people who have Joint instability when taking Melatonin? *

female: 78.57 %
male: 21.43 %

What is the age of people who have Joint instability when taking Melatonin? *

What are other drugs people take besides Melatonin? *

Vitamin B12: 7 people, 50.00%
Vitamin D3: 6 people, 42.86%
Humira: 5 people, 35.71%
Ocrevus: 4 people, 28.57%
Vitamin D: 3 people, 21.43%
Metformin: 3 people, 21.43%
Zofran: 2 people, 14.29%
Rytary: 2 people, 14.29%
Ampyra: 2 people, 14.29%
Carbidopa, Levodopa And Entacapone: 2 people, 14.29%

What are other side effects people have besides Joint instability? *

Fall: 7 people, 50.00%
Weakness: 5 people, 35.71%
Pain: 3 people, 21.43%
Headache (pain in head): 3 people, 21.43%
Gait Disturbance: 3 people, 21.43%
Fatigue (feeling of tiredness): 3 people, 21.43%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 3 people, 21.43%
Weight Decreased: 3 people, 21.43%
Procedural Pain: 3 people, 21.43%
Migraine (headache): 2 people, 14.29%

What are the existing conditions these people have? *

Pain: 4 people, 28.57%
High Blood Pressure: 4 people, 28.57%
Depression: 3 people, 21.43%
Indigestion: 3 people, 21.43%
Diabetes: 3 people, 21.43%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 14.29%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 14.29%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 14.29%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 14.29%
Progressive Multiple Sclerosis (chronic autoimmune disease of the central nervous system in which gradual destruction of myelin occurs in patches throughout the brain or spinal cord): 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

Do you take Melatonin and have Joint instability?

- Check whether Joint instability is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Melatonin:

Melatonin (56,208 reports)

Browse all side effects of Melatonin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint instability:

Joint instability (236 drugs)

Browse all the conditions that are associated with Joint instability:

Joint instability (370 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on melatonin (the active ingredients of Melatonin) and Melatonin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.