Melphalan and Primary sequestrum - a phase IV clinical study of FDA data

Summary:

Primary sequestrum is reported as a side effect among people who take Melphalan (melphalan), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Zometa, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Primary sequestrum when taking Melphalan. It is created by eHealthMe based on reports of 20,050 people who have side effects when taking Melphalan from the FDA, and is updated regularly.

What is Melphalan?

Melphalan has active ingredients of melphalan. eHealthMe is studying from 20,052 Melphalan users. Check the latest studies of Melphalan.

What is Primary sequestrum?

Primary sequestrum (piece of dead bone that has become separated during the process of necrosis from normal/sound bone) is found to be associated with 609 drugs and 320 conditions by eHealthMe. Check the latest studies of Primary sequestrum.

On Sep, 11, 2025

20,050 people reported to have side effects when taking Melphalan.
Among them, 19 people (0.09%) have Primary sequestrum.

Could Melphalan cause Primary sequestrum?

Among these 19 people:

How long have people been on Melphalan when they have Primary sequestrum? *

What is the gender of people who have Primary sequestrum when taking Melphalan? *

female: 63.16 %
male: 36.84 %

What is the age of people who have Primary sequestrum when taking Melphalan? *

What are other drugs people take besides Melphalan? *

What are other side effects people have besides Primary sequestrum? *

Osteonecrosis Of Jaw (death of bone of jaw): 18 people, 94.74%
Pain: 17 people, 89.47%
Stress And Anxiety: 17 people, 89.47%
Anaemia (lack of blood): 15 people, 78.95%
Back Pain: 14 people, 73.68%
Fatigue (feeling of tiredness): 13 people, 68.42%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 13 people, 68.42%
Pneumonia: 13 people, 68.42%
Joint Pain: 13 people, 68.42%
Dyspnea (difficult or laboured breathing): 12 people, 63.16%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 15 people, 78.95%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 4 people, 21.05%
Depression: 3 people, 15.79%
High Blood Pressure: 3 people, 15.79%
Metastases To Bone (cancer spreads to bone): 3 people, 15.79%
Transient Ischaemic Attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 2 people, 10.53%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 10.53%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 5.26%
Joint Pain: 1 person, 5.26%
Insomnia (sleeplessness): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Melphalan and have Primary sequestrum?

- Check whether Primary sequestrum is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Melphalan:

Melphalan (20,052 reports)

Primary sequestrum treatments and more:

Primary sequestrum (2,778 reports)

How severe was Primary sequestrum and when was it recovered:

Primary sequestrum in Melphalan

Browse all side effects of Melphalan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Primary sequestrum:

Primary sequestrum (609 drugs)

Browse all the conditions that are associated with Primary sequestrum:

Primary sequestrum (320 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on melphalan (the active ingredients of Melphalan) and Melphalan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.